Palladium Catalysis Enabled Sequential C(sp3)-H/C-C Activation: Access to Vinyl γ-Lactams

被引：4
|
作者：
Barman, Madhab [1 ]
Mishra, Manmath [1 ]
Mandal, Santu [1 ]
Punniyamurthy, Tharmalingam [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, N Guwahati 781039, Guwahati, India
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 18期
关键词：
C-H OLEFINATION; INTRAMOLECULAR AMINOPALLADATION; BOND FUNCTIONALIZATION; HECK REACTION; ELIMINATION; DERIVATIVES; DISCOVERY; ALKENES; PD(II);
D O I：
10.1021/acs.orglett.4c00710
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd(II)-catalyzed tandem reaction of aliphatic amides with vinylcyclopropanes (VCPs) was accomplished by merging C(sp(3))-H and C-C activation. The reaction of VCP revealed alkenylation/cyclization, followed by ring opening via C-C cleavage, delivering vinyl gamma-lactams with (E)-selectivity. The role of ligands, site-selectivity, functional group diversity, mechanistic insight, and synthetic utilities are important practical features.
引用
收藏
页码：3722 / 3726
页数：5
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