Chronic Traumatic Encephalopathy as the Course of Alzheimer's Disease

被引：2

作者：

Pszczolowska, Magdalena ^{[1
]}

Walczak, Kamil ^{[1
]}

Miskow, Weronika ^{[1
]}

Antosz, Katarzyna ^{[1
]}

Batko, Joanna ^{[1
]}

Kurpas, Donata ^{[2
]}

Leszek, Jerzy ^{[3
]}

机构：

[1] Wroclaw Med Univ, Fac Med, Ludw Pasteura 1, PL-50367 Wroclaw, Poland

[2] Wroclaw Med Univ, Fac Hlth Sci, Ul Kazimierza Bartla 5, PL-51618 Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Psychiat, Clin Psychiat, Ludw Pasteura 10, PL-50367 Wroclaw, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 09期

关键词：

chronic traumatic encephalopathy; traumatic brain injury; Alzheimer's Disease; oxidative stress; dementia; cognitive skills; KAPPA-B ACTIVATION; BRAIN-INJURY; OXIDATIVE STRESS; NEUROVASCULAR DYSFUNCTION; COGNITIVE IMPAIRMENT; TAU PHOSPHORYLATION; NITRIC-OXIDE; MOUSE MODEL; STEM-CELLS; COMPLEX-I;

D O I：

10.3390/ijms25094639

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This editorial investigates chronic traumatic encephalopathy (CTE) as a course of Alzheimer's disease (AD). CTE is a debilitating neurodegenerative disease that is the result of repeated mild traumatic brain injury (TBI). Many epidemiological studies show that experiencing a TBI in early or middle life is associated with an increased risk of dementia later in life. Chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD) present a series of similar neuropathological features that were investigated in this work like recombinant tau into filaments or the accumulation and aggregation of A beta protein. However, these two conditions differ from each other in brain-blood barrier damage. The purpose of this review was to evaluate information about CTE and AD from various articles, focusing especially on new therapeutic possibilities for the improvement in cognitive skills.

引用

页数：19

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