Afamelanotide in protoporphyria and other skin diseases: a review

被引：1
作者：
Polanska, Adriana [1 ,3 ]
Wegner, Joanna [2 ]
Nutbohm, Paula [2 ]
Staubach, Petra [2 ]
Zaba, Ryszard [1 ]
Danczak-Pazdrowska, Aleksandra [1 ]
Jenerowicz, Dorota [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Dermatol, Poznan, Poland
[2] Univ Med Ctr Mainz, Dept Dermatol, Mainz, Germany
[3] Univ Med Sci, Dept Dermatol, 49 Przybyszewskiego St, PL-60355 Poznan, Poland
来源：
POSTEPY DERMATOLOGII I ALERGOLOGII | 2024年 / 41卷 / 02期
基金：
英国科研创新办公室;
关键词：
afamelanotide; protoporphyria; erythropoietic porphyria; MELANOCYTE-STIMULATING HORMONE; ULTRAVIOLET-B PHOTOTHERAPY; ERYTHROPOIETIC PROTOPORPHYRIA; ALPHA-MELANOTROPIN; GENE VARIANTS; BETA-CAROTENE; ANALOG; PIGMENTATION; VITILIGO; EFFICACY;
D O I：
10.5114/ada.2024.138818
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Afamelanotide is a synthetic alpha melanocyte stimulating hormone presenting a higher activity than natural hormones. Its main properties are related to the enhanced production of eumelanin by agonistically binding to the melanocortin-1 receptor. Since 2016 afamelanotide has been especially applied to treat cases of erythropoietic porphyria (EPP), where painful photosensitivity has been observed since early childhood. The positive effect of af - amelanotide in EPP administered subcutaneously improved tolerance to artificial white light and increased pain -free time spent in direct sunlight. In this review we summarize the possible use of afamelanotide in dermatology, with special emphasis on EPP and encourage including afamelanotide as a treatment option in patient care.
引用
收藏
页码：149 / 154
页数：6
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