SARS-CoV-2 Humoral and Cellular Immune Responses in People Living with HIV

被引：0

作者：

Ruta, Simona ^{[1
,2
]}

Popescu, Corneliu Petru ^{[1
,3
]}

Matei, Lilia ^{[2
]}

Grancea, Camelia ^{[2
]}

Paun, Adrian Marius ^{[3
]}

Oprea, Cristiana ^{[1
,3
]}

Sultana, Camelia ^{[1
,2
]}

机构：

[1] Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania

[2] Stefan S Nicolau Inst Virol, Bucharest 030304, Romania

[3] Dr Victor Babes Hosp Infect & Trop Dis, Bucharest, Romania

来源：

VACCINES | 2024年 / 12卷 / 06期

关键词：

COVID-19; SARS-CoV-2; vaccination; cellular; humoral immune response; immunosuppression; VACCINE; IMMUNOGENICITY; INFECTION; COVID-19;

D O I：

10.3390/vaccines12060663

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunosuppressed individuals, such as people living with HIV (PLWH), remain vulnerable to severe COVID-19. We analyzed the persistence of specific SARS-CoV-2 humoral and cellular immune responses in a retrospective, cross-sectional study in PLWH on antiretroviral therapy. Among 104 participants, 70.2% had anti-S IgG antibodies, and 55.8% had significant neutralizing activity against the Omicron variant in a surrogate virus neutralization test. Only 38.5% were vaccinated (8.76 +/- 4.1 months prior), all displaying anti-S IgG, 75% with neutralizing antibodies and anti-S IgA. Overall, 29.8% of PLWH had no SARS-CoV-2 serologic markers; they displayed significantly lower CD4 counts and higher HIV viral load. Severe immunosuppression (present in 12.5% of participants) was linked to lower levels of detectable anti-S IgG (p = 0.0003), anti-S IgA (p < 0.0001) and lack of neutralizing activity against the Omicron variant (p < 0.0001). T-cell responses were present in 86.7% of tested participants, even in those lacking serological markers. In PLWH without severe immunosuppression, neutralizing antibodies and T-cell responses persisted for up to 9 months post-infection or vaccination. Advanced immunosuppression led to diminished humoral immune responses but retained specific cellular immunity.

引用

页数：13

共 60 条

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