Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens

被引：0

作者：

Marinelli, Tina ^{[1
]}

Kim, Hannah Yejin ^{[2
,3
,4
]}

Halliday, Catriona L. ^{[5
]}

Garnham, Katherine ^{[6
]}

Bupha-Intr, Olivia ^{[7
]}

Dao, Aiken ^{[2
,8
,9
]}

Morris, Arthur J. ^{[10
]}

Alastruey-Izquierdo, Ana ^{[11
]}

Colombo, Arnaldo ^{[12
]}

Rickerts, Volker ^{[13
]}

Perfect, John ^{[14
]}

Denning, David W. ^{[15
]}

Nucci, Marcio ^{[16
,17
]}

Hamers, Raph L. ^{[18
,19
]}

Cassini, Alessandro ^{[20
,21
]}

Oladele, Rita ^{[22
]}

Sorrell, Tania C. ^{[2
,4
]}

Ramon-Pardo, Pilar ^{[23
]}

Fusire, Terence ^{[24
]}

Chiller, Tom M. ^{[25
]}

Wahyuningsih, Retno ^{[26
,27
]}

Forastiero, Agustina ^{[23
]}

Al-Nuseirat, Adi ^{[28
]}

Beyer, Peter ^{[29
]}

Gigante, Valeria ^{[30
]}

Beardsley, Justin ^{[2
,31
]}

Sati, Hatim ^{[30
]}

Alffenaar, Jan-Willem ^{[2
,3
,4
]}

Morrissey, C. Orla ^{[32
,33
]}

机构：

[1] Royal Prince Alfred Hosp, Dept Infect Dis & Microbiol, Sydney, Australia

[2] Univ Sydney, Sydney Infect Dis Inst Sydney ID, Sydney, NSW, Australia

[3] Univ Sydney, Fac Med & Hlth, Sch Pharm, Sydney, NSW, Australia

[4] Westmead Hosp, Dept Pharm, Westmead, NSW, Australia

[5] Westmead Hosp, Inst Clin Pathol & Med Res, Ctr Infect Dis & Microbiol Lab Serv, New South Wales Hlth Pathol, Westmead, NSW, Australia

[6] Gold Coast Univ Hosp, Dept Infect Dis & Microbiol, Southport, Qld, Australia

[7] Wellington Reg Hosp, Dept Infect Serv, Wellington, New Zealand

[8] Univ Sydney, Fac Med & Hlth, Sydney Med Sch, Camperdown, NSW, Australia

[9] Childrens Hosp Westmead, Westmead, NSW, Australia

[10] Auckland City Hosp, Dept Clin Microbiol, Auckland, New Zealand

[11] Inst Salud Carlos III, Mycol Reference Lab, Natl Ctr Microbiol, Madrid, Spain

[12] Univ Fed Sao Paulo UNIFESP, Hosp Sao Paulo, Dept Med, Div Infect Dis,Escola Paulista Med EPM, Sao Paulo, Brazil

[13] Robert Koch Inst Berlin, Berlin, Germany

[14] Duke Univ, Sch Med, Div Infect Dis & Int Hlth, Durham, NC USA

[15] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester Fungal Infect Grp, Fac Biol Med & Hlth, Manchester, England

[16] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

[17] Grp Oncoclin, Rio De Janeiro, Brazil

[18] Univ Indonesia, Fac Med, Oxford Univ Clin Res Unit Indonesia, Jakarta, Indonesia

[19] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

[20] Lausanne Univ Hosp, Infect Dis Serv, Lausanne, Switzerland

[21] Publ Hlth Dept, Lausanne, Switzerland

[22] Univ Lagos, Coll Med, Dept Med Microbiol & Parasitol, Lagos, Nigeria

[23] Pan Amer Hlth Org, Dept Communicable Dis Prevent Control & Eliminat, Washington, DC USA

[24] World Hlth Org, South East Asia Reg Off, New Delhi, India

[25] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA

[26] Univ Indonesia, Fac Med, Dept Parasitol, Jakarta, Indonesia

[27] Univ Kristen, Fac Med, Dept Parasitol, Jakarta, Indonesia

[28] World Hlth Org, Dept Hlth Syst, Reg Off Eastern Mediterranean, Cairo, Egypt

[29] Drugs Neglected Dis Initiat, Global Antibiot Res & Dev Partnership, Geneva, Switzerland

[30] World Hlth Org, AMR Div, Geneva, Switzerland

[31] Westmead Inst Med Res, Westmead, NSW, Australia

[32] Alfred Hlth, Dept Infect Dis, Level 2,Burnet Bldg,85 Commercial Rd, Melbourne, Vic, Australia

[33] Monash Univ, Level 2,Burnet Bldg,85 Commercial Rd, Melbourne, Vic, Australia

来源：

MEDICAL MYCOLOGY | 2024年 / 62卷 / 06期

关键词：

Fusarium; Scedosporium apiospermum; Lomentospora prolificans; invasive fungal disease; fungemia; antifungal resistance; mortality; epidemiology; VITRO ANTIFUNGAL SUSCEPTIBILITY; INVASIVE SCEDOSPORIUM SPP; SUPERFICIAL SKIN-LESIONS; CLINICAL CHARACTERISTICS; CYSTIC-FIBROSIS; INFECTIONS; THERAPY; PSEUDALLESCHERIA; EPIDEMIOLOGY; APIOSPERMUM;

D O I：

10.1093/mmy/myad128

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Recognizing the growing global burden of fungal infections, the World Health Organization established a process to develop a priority list of fungal pathogens (FPPL). In this systematic review, we aimed to evaluate the epidemiology and impact of infections caused by Fusarium spp., Scedosporium spp., and Lomentospora prolificans to inform the first FPPL. PubMed and Web of Sciences databases were searched to identify studies published between January 1, 2011 and February 23, 2021, reporting on mortality, complications and sequelae, antifungal susceptibility, preventability, annual incidence, and trends. Overall, 20, 11, and 9 articles were included for Fusarium spp., Scedosporium spp., and L. prolificans, respectively. Mortality rates were high in those with invasive fusariosis, scedosporiosis, and lomentosporiosis (42.9%-66.7%, 42.4%-46.9%, and 50.0%-71.4%, respectively). Antifungal susceptibility data, based on small isolate numbers, showed high minimum inhibitory concentrations (MIC)/minimum effective concentrations for most currently available antifungal agents. The median/mode MIC for itraconazole and isavuconazole were >= 16 mg/l for all three pathogens. Based on limited data, these fungi are emerging. Invasive fusariosis increased from 0.08 cases/100 000 admissions to 0.22 cases/100 000 admissions over the time periods of 2000-2009 and 2010-2015, respectively, and in lung transplant recipients, Scedosporium spp. and L. prolificans were only detected from 2014 onwards. Global surveillance to better delineate antifungal susceptibility, risk factors, sequelae, and outcomes is required.

引用

页数：34