Gastrointestinal digestion of food proteins: Anticancer, antihypertensive, anti-obesity, and immunomodulatory mechanisms of the derived peptides

被引:13
作者
Yan, Zheng [1 ]
Gui, Yang [1 ]
Liu, Chunhong [1 ]
Zhang, Xiaohai [1 ]
Wen, Chaoling [2 ]
Olatunji, Opeyemi Joshua [3 ]
Suttikhana, Itthanan [4 ]
Ashaolu, Tolulope Joshua [5 ,6 ]
机构
[1] Second Peoples Hosp Wuhu City, Wuhu, Anhui, Peoples R China
[2] Anhui Coll Tradit Chinese Med, Wuhu 241000, Anhui, Peoples R China
[3] Mohammed VI Polytech Univ, African Genome Ctr, Ben Guerir 43150, Morocco
[4] Univ South Bohemia Ceske Budejovice, Fac Agr & Technol, Dept Agroecosyst, Branisovska 1645-31A, Ceske Budejovice 2, Czech Republic
[5] Duy Tan Univ, Inst Global Hlth Innovat, Da Nang 550000, Vietnam
[6] Duy Tan Univ, Fac Med, Da Nang 550000, Vietnam
关键词
Food proteins; Food -based peptides; Bioactive peptides; Mechanisms; Gastrointestinal digestion; ANGIOTENSIN-CONVERTING ENZYME; ACE INHIBITORY PEPTIDE; BIOACTIVE PEPTIDES; GUT MICROBIOTA; SOY PROTEIN; BIOCHEMICAL-CHARACTERIZATION; ANTIINFLAMMATORY PEPTIDES; INDUCE APOPTOSIS; DIETARY-PROTEIN; ANTIOXIDANT;
D O I
10.1016/j.foodres.2024.114573
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Food proteins and their peptides play a significant role in the important biological processes and physiological functions of the body. The peptides show diverse biological benefits ranging from anticancer to antihypertensive, anti -obesity, and immunomodulatory, among others. In this review, an overview of food protein digestion in the gastrointestinal tract and the mechanisms involved was presented. As some proteins remain resistant and undigested, the multifarious factors (e.g. protein type and structure, microbial composition, pH levels and redox potential, host factors, etc.) affecting their colonic fermentation, the derived peptides, and amino acids that evade intestinal digestion are thus considered. The section that follows focuses on the mechanisms of the peptides with anticancer, antihypertensive, anti -obesity, and immunomodulatory effects. As further considerations were made, it is concluded that clinical studies targeting a clear understanding of the gastrointestinal stability, bioavailability, and safety of food -based peptides are still warranted.
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页数:14
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