Nanodrug Delivery Systems in Antitumor Immunotherapy

被引：8

作者：

Guo, Zishuo ^{[1
]}

Ye, Jinhong ^{[1
]}

Cheng, Xuehao ^{[1
]}

Wang, Tieshan ^{[1
]}

Zhang, Yi ^{[2
]}

Yang, Kaili ^{[1
]}

Du, Shouying ^{[1
]}

Li, Pengyue ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Beijing 102488, Peoples R China

[2] YiDu Cent Hosp Weifang, Weifang 262500, Shandong, Peoples R China

来源：

BIOMATERIALS RESEARCH | 2024年 / 28卷

基金：

中国国家自然科学基金;

关键词：

CAR-T-CELLS; TUMOR MICROENVIRONMENT; CANCER-IMMUNOTHERAPY; PHOTODYNAMIC THERAPY; CHECKPOINT BLOCKADE; PD-L1; EXPRESSION; NANOPARTICLES; NANOMEDICINE; IMMUNITY; CHEMOTHERAPY;

D O I：

10.34133/bmr.0015

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Cancer has become one of the most important factors threatening human health, and the global cancer burden has been increasing rapidly. Immunotherapy has become another clinical research hotspot after surgery, chemotherapy, and radiotherapy because of its high efficiency and tumor metastasis prevention. However, problems such as lower immune response rate and immune-related adverse reaction in the clinical application of immunotherapy need to be urgently solved. With the development of nanodrug delivery systems, various nanocarrier materials have been used in the research of antitumor immunotherapy with encouraging therapeutic results. In this review, we mainly summarized the combination of nanodrug delivery systems and immunotherapy from the following 4 aspects: (a) nanodrug delivery systems combined with cytokine therapy to improve cytokines delivery in vivo; (b) nanodrug delivery systems provided a suitable platform for the combination of immune checkpoint blockade therapy with other tumor treatments; (c) nanodrug delivery systems helped deliver antigens and adjuvants for tumor vaccines to enhance immune effects; and (d) nanodrug delivery systems improved tumor treatment efficiency and reduced toxicity for adoptive cell therapy. Nanomaterials chosen by researchers to construct nanodrug delivery systems and their function were also introduced in detail. Finally, we discussed the current challenges and future prospects in combining nanodrug delivery systems with immunotherapy.

引用

页数：31

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