Novel Heteroaryl Compounds as CD73 Inhibitors for Treating Cancer

被引:1
作者
Sabnis, Ram W. [1 ]
机构
[1] Smith Gambrell & Russell LLP, Atlanta, GA 30309 USA
来源
ACS MEDICINAL CHEMISTRY LETTERS | 2024年 / 15卷 / 06期
关键词
D O I
10.1021/acsmedchemlett.4c00230
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Provided herein are novel heteroaryl compounds as CD73 inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.
引用
收藏
页码:775 / 776
页数:2
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  • [1] Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma
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    Richardson, Paul
    Atanackovic, Djordje
    Chini, Eduardo
    Chng, Wee Joo
    Van De Velde, Helgi
    Malavasi, Fabio
    [J]. CANCER MEDICINE, 2023, 12 (20): : 20332 - 20352
  • [2] Small molecular CD73 inhibitors: Recent progress and future perspectives
    Ge, Gong-hui
    Wang, Qiu-yin
    Zhang, Zhen-hao
    Zhang, Xu
    Guo, Shuai
    Zhang, Ting-jian
    Meng, Fan-hao
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 264
  • [3] CD73 in glioblastoma: Where are we now and what are the future directions?
    Gelsleichter, Nicolly Espindola
    Azambuja, Juliana Hofstatter
    Rubenich, Dominique Santos
    Braganhol, Elizandra
    [J]. IMMUNOLOGY LETTERS, 2023, 256 : 20 - 27
  • [4] Metabolic interplay: tumor macrophages and regulatory T cells
    Vilbois, Stefania
    Xu, Yingxi
    Ho, Ping-Chih
    [J]. TRENDS IN CANCER, 2024, 10 (03) : 242 - 255
  • [5] Chimeric antigen receptor natural killer cells: a promising antitumor immunotherapy
    Wang, Yan
    Jin, Shengjie
    Zhuang, Qiqi
    Liu, Na
    Chen, Ruyi
    Adam, Sofia Abdulkadir
    Jin, Jie
    Sun, Jie
    [J]. MEDCOMM, 2023, 4 (06):
  • [6] Advances in CD73 inhibitors for immunotherapy: Antibodies, synthetic small molecule compounds, and natural compounds
    Zhang, Mingxue
    Dai, Xiaoqin
    Xiang, Yu
    Xie, Linshen
    Sun, Minghan
    Shi, Jianyou
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 258