GPX4, ferroptosis, and diseases

被引：39
|
作者：
Zhang, Wangzheqi [1 ]
Liu, Yang [1 ]
Liao, Yan [1 ]
Zhu, Chenglong [1 ]
Zou, Zui [1 ]
机构：
[1] Naval Med Univ, Sch Anesthesiol, 168 Changhai Rd, Shanghai 200433, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2024年 / 174卷
关键词：
GPX4; Ferroptosis; Sepsis; Nervous system diseases; Ischemia reperfusion injury; Cardiovascular diseases; Cancer; GLUTATHIONE-PEROXIDASE; 4; CELL-DEATH; REPERFUSION INJURY; OXIDATIVE STRESS; NUCLEAR FORM; EXPRESSION; PROTEIN; CANCER; IDENTIFICATION; SEPSIS;
D O I：
10.1016/j.biopha.2024.116512
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
GPX4 (Glutathione peroxidase 4) serves as a crucial intracellular regulatory factor, participating in various physiological processes and playing a significant role in maintaining the redox homeostasis within the body. Ferroptosis, a form of iron-dependent non-apoptotic cell death, has gained considerable attention in recent years due to its involvement in multiple pathological processes. GPX4 is closely associated with ferroptosis and functions as the primary inhibitor of this process. Together, GPX4 and ferroptosis contribute to the pathophysiology of several diseases, including sepsis, nervous system diseases, ischemia reperfusion injury, cardiovascular diseases, and cancer. This review comprehensively explores the regulatory roles and impacts of GPX4 and ferroptosis in the development and progression of these diseases, with the aim of providing insights for identifying potential therapeutic strategies in the future.
引用
收藏
页数：15
相关论文
共 50 条
  • [21] Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia
    Hiroki Akiyama
    Ran Zhao
    Lauren B. Ostermann
    Ziyi Li
    Matthew Tcheng
    Samar J. Yazdani
    Arman Moayed
    Malcolm L. Pryor
    Sandeep Slngh
    Natalia Baran
    Edward Ayoub
    Yuki Nishida
    Po Yee Mak
    Vivian R. Ruvolo
    Bing Z. Carter
    Aaron D. Schimmer
    Michael Andreeff
    Jo Ishizawa
    Leukemia, 2024, 38 : 729 - 740
  • [22] Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
    Ingold, Irina
    Berndt, Carsten
    Schmitt, Sabine
    Doll, Sebastian
    Poschmann, Gereon
    Buday, Katalin
    Roveri, Antonella
    Peng, Xiaoxiao
    Freitas, Florencio Porto
    Seibt, Tobias
    Mehr, Lisa
    Aichler, Michaela
    Walch, Axel
    Lamp, Daniel
    Jastroch, Martin
    Miyamoto, Sayuri
    Wurst, Wolfgang
    Ursini, Fulvio
    Amer, Elias S. J.
    Fradejas-Villar, Noelia
    Schweizer, Ulrich
    Zischka, Hans
    Angeli, Jose Pedro Friedmann
    Conrad, Marcus
    CELL, 2018, 172 (03) : 409 - +
  • [23] Curcumol promotes ferroptosis of colon cancer by targeting the ubiquitination and degradation of GPX4
    Zhao, Wuxia
    Yan, Qiuying
    Liu, Lianfang
    Hou, Dahai
    Xiang, Dongyang
    Tang, Dongxin
    Li, Liu
    Shen, Weixing
    Tao, Weiwei
    Cheng, Haibo
    Sun, Dongdong
    JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE, 2025, 15 (02): : 170 - 181
  • [24] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
    Jose Pedro Friedmann Angeli
    Manuela Schneider
    Bettina Proneth
    Yulia Y. Tyurina
    Vladimir A. Tyurin
    Victoria J. Hammond
    Nadja Herbach
    Michaela Aichler
    Axel Walch
    Elke Eggenhofer
    Devaraj Basavarajappa
    Olof Rådmark
    Sho Kobayashi
    Tobias Seibt
    Heike Beck
    Frauke Neff
    Irene Esposito
    Rüdiger Wanke
    Heidi Förster
    Olena Yefremova
    Marc Heinrichmeyer
    Georg W. Bornkamm
    Edward K. Geissler
    Stephen B. Thomas
    Brent R. Stockwell
    Valerie B. O’Donnell
    Valerian E. Kagan
    Joel A. Schick
    Marcus Conrad
    Nature Cell Biology, 2014, 16 : 1180 - 1191
  • [25] Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis
    Imai, Hirotaka
    Matsuoka, Masaki
    Kumagai, Takeshi
    Sakamoto, Taro
    Koumura, Tomoko
    APOPTOTIC AND NON-APOPTOTIC CELL DEATH, 2017, 403 : 143 - 170
  • [26] Discovery of GPX4 inhibitor by molecular docking simulation as a potential ferroptosis inducer
    Fatonah, Ani
    Tambunan, Usman Sumo Friend
    Pamungkas, Wilis Okti
    Dewanto, Gana Lahirin
    Wicaksono, Ig Satrio
    BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2020, 10 (01): : 4929 - 4933
  • [27] GPx4 reduces laser-induced choroidal neovascularization by inhibiting ferroptosis
    Qu, Sichang
    Grus, Franz
    ACTA OPHTHALMOLOGICA, 2022, 100
  • [28] Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity
    Guo, Cao
    Liu, Ping
    Deng, Ganlu
    Han, Ying
    Chen, Yihong
    Cai, Changjing
    Shen, Hong
    Deng, Gongping
    Zeng, Shan
    AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (06): : 3039 - 3054
  • [29] Targeting GPX4 alleviates ferroptosis and retards abdominal aortic aneurysm formation
    Shi, Yu
    Zhao, Yi
    Sun, Si-Jia
    Lan, Xiu-Ting
    Wu, Wen-Bin
    Zhang, Zhen
    Chen, Yu-Xin
    Yan, Yu-Ying
    Xu, Yu-Ping
    Li, Dong-Jie
    Fu, Hui
    Shen, Fu-Ming
    BIOCHEMICAL PHARMACOLOGY, 2025, 234
  • [30] A potent GPX4 degrader to induce ferroptosis in HT1080 cells
    Song, Haoze
    Liang, Jing
    Guo, Yuanyuan
    Liu, Yang
    Sa, Kuiru
    Yan, Guohong
    Xu, Wen
    Xu, Wei
    Chen, Lixia
    Li, Hua
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 265
12345