Essential Oils against Candida auris-A Promising Approach for Antifungal Activity

被引:4
作者
Kowalczyk, Adam [1 ]
机构
[1] Wroclaw Med Univ, Fac Pharm, Dept Pharmacognosy & Herbal Med, PL-50556 Wroclaw, Poland
来源
ANTIBIOTICS-BASEL | 2024年 / 13卷 / 06期
关键词
Candida auris; essential oils; antifungal agent;
D O I
10.3390/antibiotics13060568
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
The emergence of Candida auris as a multidrug-resistant fungal pathogen represents a significant global health challenge, especially given the growing issue of antifungal drug resistance. This review aims to illuminate the potential of essential oils (EOs), which are volatile plant secretions containing complex mixtures of chemicals, as alternative antifungal agents to combat C. auris, thus combining traditional insights with contemporary scientific findings to address this critical health issue. A systematic literature review was conducted using the PubMed, Scopus, and Web of Science databases from 2019 to 2024, and using the Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol to identify relevant studies on the antifungal efficacy of EOs or their components against C. auris. Of the 90 articles identified, 16 were selected for detailed review. The findings highlight the diverse mechanisms of action of EOs and their components, such as disrupting fungal cell membranes, inducing the production of reactive oxygen species (ROS), and impeding biofilm formation, suggesting that some of them may be as effective as, or better than, traditional antifungal drugs while potentially limiting the development of resistance. However, issues such as variability in the composition of EOs and a paucity of clinical trials have been identified as significant obstacles. In conclusion, EOs and their active ingredients are emerging as viable candidates for creating effective treatments for C. auris, underscoring their importance as alternative or complementary antifungal agents in the face of increasing drug resistance. The call for future research underscores the need for clinical trials and standardization to unlock the full antifungal potential of EOs against C. auris.
引用
收藏
页数:16
相关论文
共 45 条
[1]   Antifungal Properties of Essential Oils and Their Compounds for Application in Skin Fungal Infections: Conventional and Nonconventional Approaches [J].
Abd Rashed, Aswir ;
Rathi, Devi-Nair Gunasegavan ;
Ahmad Nasir, Nor Atikah Husna ;
Abd Rahman, Ahmad Zuhairi .
MOLECULES, 2021, 26 (04)
[2]   Differential Antimicrobial Effect of Essential Oils and Their Main Components: Insights Based on the Cell Membrane and External Structure [J].
Andrade-Ochoa, Sergio ;
Fabiola Chacon-Vargas, Karla ;
Enid Sanchez-Torres, Luvia ;
Estela Rivera-Chavira, Blanca ;
Nogueda-Torres, Benjamin ;
Virginia Nevarez-Moorillon, Guadalupe .
MEMBRANES, 2021, 11 (06)
[3]   Nanostructured Lipid Carriers Loaded with Lippia sidoides Essential Oil as a Strategy to Combat the Multidrug-Resistant Candida auris [J].
Baldim, Iara ;
Paziani, Mario H. ;
Grizante Bariao, Patricia H. ;
Kress, Marcia R. von Zeska ;
Oliveira, Wanderley P. .
PHARMACEUTICS, 2022, 14 (01)
[4]   Controlling a possible outbreak of Candida auris infection: lessons learnt from multiple interventions [J].
Biswal, M. ;
Rudramurthy, S. M. ;
Jain, N. ;
Shamanth, A. S. ;
Sharma, D. ;
Jain, K. ;
Yaddanapudi, L. N. ;
Chakrabarti, A. .
JOURNAL OF HOSPITAL INFECTION, 2017, 97 (04) :363-370
[5]  
cdc, CDC's Antibiotic Resistance Threats in the United States
[6]   A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance [J].
Chowdhary, Anuradha ;
Prakash, Anupam ;
Sharma, Cheshta ;
Kordalewska, Milena ;
Kumar, Anil ;
Sarma, Smita ;
Tarai, Bansidhar ;
Singh, Ashutosh ;
Upadhyaya, Gargi ;
Upadhyay, Shalini ;
Yadav, Priyanka ;
Singh, Pradeep K. ;
Khillan, Vikas ;
Sachdeva, Neelam ;
Perlin, David S. ;
Meis, Jacques F. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2018, 73 (04) :891-899
[7]   Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally [J].
Chowdhary, Anuradha ;
Sharma, Cheshta ;
Meis, Jacques F. .
PLOS PATHOGENS, 2017, 13 (05)
[8]   Antifungal Activity of Essential Oils Against Candida Species Isolated from Clinical Samples [J].
Cordoba, S. ;
Vivot, W. ;
Szusz, W. ;
Albo, G. .
MYCOPATHOLOGIA, 2019, 184 (05) :615-623
[9]  
Day AM, 2018, MSPHERE, V3, DOI [10.1128/mSphere.00506-18, 10.1128/msphere.00506-18]
[10]   Activity of Free and Liposome-Encapsulated Essential Oil from Lavandula angustifolia against Persister-Derived Biofilm of Candida auris [J].
de Alteriis, Elisabetta ;
Maione, Angela ;
Falanga, Annarita ;
Bellavita, Rosa ;
Galdiero, Stefania ;
Albarano, Luisa ;
Salvatore, Maria Michela ;
Galdiero, Emilia ;
Guida, Marco .
ANTIBIOTICS-BASEL, 2022, 11 (01)