Bimekizumab for the Treatment of Plaque Psoriasis with Involvement of Genitalia: A 16-Week Multicenter Real-World Experience - IL PSO (Italian Landscape Psoriasis)

被引:20
作者
Orsini, Diego [1 ,28 ]
Malagoli, Piergiorgio [2 ]
Balato, Anna [3 ]
Bianchi, Luca [4 ]
Brianti, Pina [5 ]
Buononato, Dario [3 ]
Burlando, Martina [6 ]
Caldarola, Giacomo [7 ,8 ]
Campanati, Anna [9 ]
Campione, Elena [4 ]
Carrera, Carlo G. [10 ]
Carugno, Andrea [11 ,12 ]
Cusano, Francesco [13 ]
Dapavo, Paolo [14 ]
Dattola, Annunziata [15 ]
De Simone, Clara [7 ,8 ]
Dini, Valentina [16 ]
Esposito, Maria [17 ]
Fargnoli, Maria C. [17 ]
Gaiani, Francesca M. [2 ]
Gargiulo, Luigi [18 ,19 ]
Gisondi, Paolo [20 ]
Giunta, Alessandro [4 ]
Ibba, Luciano [18 ,19 ]
Lasagni, Claudia [21 ]
Loconsole, Francesco [22 ]
Maione, Vincenzo [23 ]
Mortato, Edoardo [22 ]
Marzano, Angelo, V [10 ,24 ]
Maurelli, Martina [20 ]
Megna, Matteo [25 ]
Mercuri, Santo R. [5 ,26 ]
Narcisi, Alessandra [18 ]
Offidani, Annamaria [10 ]
Paolino, Giovanni [5 ]
Parodi, Aurora [6 ]
Pellacani, Giovanni [15 ]
Potestio, Luca [25 ]
Quaglino, Pietro [14 ]
Richetta, Antonio G. [15 ]
Romano, Francesca [27 ]
Sena, Paolo [11 ]
Venturini, Marina [23 ]
Assorgi, Chiara [1 ,25 ]
Costanzo, Antonio [18 ,19 ]
机构
[1] San Gallicano Dermatol Inst IRCCS, Clin Dermatol Unit, Rome, Italy
[2] Azienda Osped San Donato Milanese, Dept Dermatol, Dermatol Unit, Milan, Italy
[3] Univ Campania L Vanvitelli, Dermatol Unit, Naples, Italy
[4] Univ Roma Tor Vergata, Dept Syst Med, Dermatol, Rome, Italy
[5] IRCCS San Raffaele Sci Inst, Unit Dermatol & Cosmetol, Milan, Italy
[6] IRCCS San Martino Univ Hosp, Dept Hlth Sci DISSAL, Sect Dermatol, Genoa, Italy
[7] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Sect Dermatol, Rome, Italy
[8] Agostino Gemelli Univ Polyclin Fdn, Dermatol Unit, IRCCS, Rome, Italy
[9] Univ Politecn Marche, Dept Clin & Mol Sci, Dermatol Clin, Ancona, Italy
[10] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dermatol Unit, Milan, Italy
[11] ASST Papa Giovanni XXIII Hosp, Dermatol Unit, Bergamo, Italy
[12] Univ Milano Bicocca, Mol & Translat Med DIMET, Milan, Italy
[13] Gaetano Rummo Hosp, Dept Dermatol, Benevento, Italy
[14] Univ Turin, Dept Biomed Sci & Human Oncol, Dermatol Clin 2, Turin, Italy
[15] Univ Roma La Sapienza, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Dermatol Unit, Rome, Italy
[16] Osped Santa Chiara, Dept Clin & Expt Med, Dermatol Unit, Pisa, Italy
[17] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Dermatol, Laquila, Italy
[18] IRCCS Humanitas Res Hosp, Dermatol Unit, Milan, Italy
[19] Humanitas Univ, Dept Biomed Sci, Milan, Italy
[20] Univ Verona, Dept Med, Sect Dermatol & Venereol, Verona, Italy
[21] Univ Modena, Dept Specialized Med, Dermatol Clin, Modena, Italy
[22] Univ Bari, Dept Dermatol, Bari, Italy
[23] ASST Spedali Civili Hosp, Dept Dermatol, Brescia, Italy
[24] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy
[25] Univ Naples Federico II, Dept Clin Med & Surg, Sect Dermatol, Naples, Italy
[26] Univ Vita Salute San Raffaele, Milan, Italy
[27] Dermatol Unit, AORN A Cardarelli, Naples, Italy
[28] San Gallicano Dermatol Inst IRCCS, Clin Dermatol Unit, I-00144 Rome, RM, Italy
关键词
immonumodulatory therapies; Inflammatory Skin Diseases; psoriasis; psoriasis treatment; DOUBLE-BLIND; MODERATE; PLACEBO; EFFICACY; 52-WEEK; SAFETY; IMPACT;
D O I
10.5826/dpc.1402a52
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Introduction: Genital involvement is observed in approximately 60% of patients with psoriasis, presenting clinicians with formidable challenges in treatment. While new biologic drugs have emerged as safe and effective options for managing psoriasis, their efficacy in challenging-to-treat areas remains inadequately explored. Intriguingly, studies have shown that interleukin (IL)-17 inhibitors exhibit effectiveness in addressing genital psoriasis. Objectives: We aimed to determine the effectiveness profile of bimekizumab in patients affected by moderate-to-severe plaque psoriasis with involvement of genitalia. Methods: Bimekizumab, a dual inhibitor of both IL-17A and IL-17F, was the focus of our 16-week study, demonstrating highly favorable outcomes for patients with genital psoriasis. The effectiveness of bimekizumab was evaluated in terms of improvement in Static Physician's Global Assessment of Genitalia (sPGA-G) and Psoriasis Area and Severity Index. Results: Sixty-five adult patients were enrolled. Remarkably, 98.4% of our participants achieved a clear sPGA-G score (s-PGA-g=0) within 16 weeks. Moreover, consistent improvements were observed in PASI scores, accompanied by a significant reduction in the mean Dermatology Life Quality Index (DLQI), signifying enhanced quality of life. Notably, none of the patients reported a severe impairment in their quality of life after 16 weeks of treatment. In our cohort of 65 patients, subgroup analyses unveiled that the effectiveness of bimekizumab remained unaffected by prior exposure to other biologics or by obesity. Conclusions: Our initial findings suggest that bimekizumab may serve as a valuable treatment option for genital psoriasis. Nevertheless, further research with larger sample sizes and longer-term follow-up is imperative to conclusively validate these results.
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页数:9
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