The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection

被引：9

作者：

Starvaggi, Jose ^{[1
]}

Previti, Santo ^{[1
]}

Zappala, Maria ^{[1
]}

Ettari, Roberta ^{[1
]}

机构：

[1] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Ferdinando Stagno dAlcontres 31, I-98166 Messina, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 08期

关键词：

dengue virus; zika virus; NS2B/NS3 serine protease; antiviral agents; orthosteric and allosteric inhibitors; NS2B-NS3; PROTEASE; PEPTIDE INHIBITORS; NS3; ANTIVIRAL ACTIVITY; CRYSTAL-STRUCTURE; BIOLOGICAL EVALUATION; FLAVIVIRAL PROTEASES; CELL-PERMEABILITY; MESSENGER-RNA; DISCOVERY;

D O I：

10.3390/ijms25084376

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the global pandemic scenario, dengue and zika viruses (DENV and ZIKV, respectively), both mosquito-borne members of the flaviviridae family, represent a serious health problem, and considering the absence of specific antiviral drugs and available vaccines, there is a dire need to identify new targets to treat these types of viral infections. Within this drug discovery process, the protease NS2B/NS3 is considered the primary target for the development of novel anti-flavivirus drugs. The NS2B/NS3 is a serine protease that has a dual function both in the viral replication process and in the elusion of the innate immunity. To date, two main classes of NS2B/NS3 of DENV and ZIKV protease inhibitors have been discovered: those that bind to the orthosteric site and those that act at the allosteric site. Therefore, this perspective article aims to discuss the main features of the use of the most potent NS2B/NS3 inhibitors and their impact at the social level.

引用

页数：22

共 79 条

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