Investigation of the linear accelerator low dose rate mode for pulsed low-dose-rate radiotherapy delivery

Purpose. Pulsed volumetric modulated arc therapy (VMAT) was proposed as an advanced treatment that combines the biological benefits of pulsed low dose rate (PLDR) and the dosimetric benefits of the intensity-modulated beams. In our conventional pulsed VMAT technique, a daily fractional dose of 200 cGy is delivered in 10 arcs with 3 min intervals between the arcs. In this study, we are testing the feasibility of pulsed VMAT that omits the need to split into ten arcs and excludes any beam-off gaps. Methods. The study was conducted using computed tomographic images of 24 patients previously treated at our institution with the conventional PLDR technique. Our newly installed Elekta machine has a low dose rate option on the order of 25 MU min-1. PLDR requires an effective dose rate of 6.7 cGy min-1 with attention being paid to the maximum dose received within any point within the target not to exceed 13 cGy min-1. The quality of treatment plans was judged based on dose-volume histograms, isodose distribution, dose conformality to the target, and target dose homogeneity. The dose delivery accuracy was assessed by measurements using the MatriXX Evolution 2D array system. Results. All cases were normalized to cover 95% of the target volume with 100% of the prescription dose. The average conformity index was 1.03 +/- 0.08 while the average homogeneity index was 1.05 +/- 0.02. The maximum reported dose rate at any point within the target was 10.44 cGy min-1. The mean dose rate for all pulsed VMAT plans was 6.88 +/- 0.1 cGy min-1. All cases passed our gamma analysis with an average passing rate of 99.00% +/- 0.48%. Conclusion. The study showed the applicability of planning pulsed VMAT using Eclipse and its successful delivery on our Elekta linac. Pulsed VMAT using the machine's low dose rate mode is more efficient than our previous pulsed VMAT delivery.