Unveiling the Influence of Copy Number Variations on Genetic Diversity and Adaptive Evolution in China's Native Pig Breeds via Whole-Genome Resequencing

被引：6

作者：

Yuan, Haonan ^{[1
]}

Wei, Wenjing ^{[1
]}

Zhang, Yue ^{[1
]}

Li, Changwen ^{[2
]}

Zhao, Shengguo ^{[1
]}

Chao, Zhe ^{[3
]}

Xia, Changyou ^{[2
]}

Quan, Jinqiang ^{[1
]}

Gao, Caixia ^{[2
]}

机构：

[1] Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou 730030, Peoples R China

[2] Chinese Acad Agr Sci CAAS, Harbin Vet Res Inst, Natl Poultry Lab Anim Resource Ctr, State Key Lab Anim Dis Control & Prevent, Harbin 150069, Peoples R China

[3] Hainan Acad Agr Sci, Inst Anim Sci & Vet Med, Key Lab Trop Anim Breeding & Dis Res, Haikou 571100, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 11期

基金：

国家重点研发计划;

关键词：

genomic analysis; selective breeding; gene-environment interaction; swine genomics; animal model applications; GENERATION; ARRAY; EXPRESSION; NCF2;

D O I：

10.3390/ijms25115843

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Copy number variations (CNVs) critically influence individual genetic diversity and phenotypic traits. In this study, we employed whole-genome resequencing technology to conduct an in-depth analysis of 50 pigs from five local swine populations [Rongchang pig (RC), Wuzhishan pig (WZS), Tibetan pig (T), Yorkshire (YL) and Landrace (LR)], aiming to assess their genetic potential and explore their prospects in the field of animal model applications. We identified a total of 96,466 CNVs, which were subsequently integrated into 7112 non-redundant CNVRs, encompassing 1.3% of the swine genome. Functional enrichment analysis of the genes within these CNVRs revealed significant associations with sensory perception, energy metabolism, and neural-related pathways. Further selective scan analyses of the local pig breeds RC, T, WZS, along with YL and LR, uncovered that for the RC variety, the genes PLA2G10 and ABCA8 were found to be closely related to fat metabolism and cardiovascular health. In the T breed, the genes NCF2 and CSGALNACT1 were associated with immune response and connective tissue characteristics. As for the WZS breed, the genes PLIN4 and CPB2 were primarily linked to fat storage and anti-inflammatory responses. In summary, this research underscores the pivotal role of CNVs in fostering the diversity and adaptive evolution of pig breeds while also offering valuable insights for further exploration of the advantageous genetic traits inherent to China's local pig breeds. This facilitates the creation of experimental animal models tailored to the specific characteristics of these breeds, contributing to the advancement of livestock and biomedical research.

引用

页数：16

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