Precision medicine in colorectal cancer: Leveraging multi-omics, spatial omics, and artificial intelligence

被引：14

作者：

Xu, Zishan ^{[1
]}

Li, Wei ^{[2
]}

Dong, Xiangyang ^{[1
]}

Chen, Yingying ^{[3
]}

Zhang, Dan ^{[1
]}

Wang, Jingnan ^{[4
]}

Zhou, Lin ^{[5
]}

He, Guoyang ^{[1
]}

机构：

[1] Xinxiang Med Univ, Dept Pathol, Xinxiang 453000, Peoples R China

[2] Xinxiang Med Univ, Sch Forens Med, Xinxiang 453000, Peoples R China

[3] Xinxiang Med Univ, Sch Basic Med Sci, Xinxiang 453000, Peoples R China

[4] Xinxiang Med Univ, SanQuan Med Coll, Xinxiang 453003, Peoples R China

[5] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Breast & Thyroid Surg, Wuhan 430022, Peoples R China

来源：

CLINICA CHIMICA ACTA | 2024年 / 559卷

关键词：

Colorectal cancer; Precision medicine; Multi-omics; Spatial omics; Artificial intelligence; Biomarkers; MICROSATELLITE INSTABILITY; COLON-CANCER; TUMOR; IDENTIFICATION; BIOMARKERS; PROTEOMICS; DISCOVERY;

D O I：

10.1016/j.cca.2024.119686

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Recent advancements in genomic technologies and analytical approaches have revolutionized CRC research, enabling precision medicine. This review highlights the integration of multi-omics, spatial omics, and artificial intelligence (AI) in advancing precision medicine for CRC. Multi-omics approaches have uncovered molecular mechanisms driving CRC progression, while spatial omics have provided insights into the spatial heterogeneity of gene expression in CRC tissues. AI techniques have been utilized to analyze complex datasets, identify new treatment targets, and enhance diagnosis and prognosis. Despite the tumor's heterogeneity and genetic and epigenetic complexity, the fusion of multi-omics, spatial omics, and AI shows the potential to overcome these challenges and advance precision medicine in CRC. The future lies in integrating these technologies to provide deeper insights and enable personalized therapies for CRC patients.

引用

页数：10

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