Effects of Raman Labeling Compounds on the Stability and Surface-Enhanced Raman Spectroscopy Performance of Ag Nanoparticle-Embedded Silica Nanoparticles as Tagging Materials

被引:1
作者
Yang, Cho-Hee [1 ]
Cho, Hye-Seong [1 ]
Kim, Yoon-Hee [1 ]
Yoo, Kwanghee [1 ]
Lim, Jaehong [2 ]
Hahm, Eunil [1 ]
Rho, Won Yeop [3 ]
Kim, Young Jun [1 ]
Jun, Bong-Hyun [1 ]
机构
[1] Konkuk Univ, Dept Biosci & Biotechnol, Seoul 05029, South Korea
[2] Nanophilia Inc, Gwacheon 13840, South Korea
[3] Jeonbuk Natl Univ, Sch Int Engn & Sci, Jeonju 54896, South Korea
来源
BIOSENSORS-BASEL | 2024年 / 14卷 / 06期
基金
新加坡国家研究基金会;
关键词
surface-enhanced Raman spectroscopy; Raman labeling compound; SERS tags; SiO2@Ag; Ag NPs; stability; period; pH; temperature; SILVER NANOPARTICLES; CORE; IMMUNOASSAY; NANOPROBES; PROBES; TAGS; SIZE;
D O I
10.3390/bios14060272
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Surface-enhanced Raman spectroscopy (SERS) tagging using silica(SiO2)@Ag nanoparticles (NPs) is easy to handle and is being studied in various fields, including SERS imaging and immunoassays. This is primarily due to its structural advantages, characterized by high SERS activity. However, the Ag NPs introduced onto the SiO2 surface may undergo structural transformation owing to the Ostwald ripening phenomenon under various conditions. As a result, the consistency of the SERS signal decreases, reducing their usability as SERS substrates. Until recently, research has been actively conducted to improve the stability of single Ag NPs. However, research on SiO2@Ag NPs used as a SERS-tagging material is still lacking. In this study, we utilized a Raman labeling compound (RLC) to prevent the structural deformation of SiO2@Ag NPs under various conditions and proposed excellent SiO2@Ag@RLC-Pre NPs as a SERS-tagging material. Using various RLCs, we confirmed that 4-mercaptobenzoic acid (4-MBA) is the RLC that maintains the highest stability for 2 months. These results were also observed for the SiO2@Ag NPs, which were unstable under various pH and temperature conditions. We believe that SERS tags using SiO2@Ag NPs and 4-MBA can be utilized in various applications on based SERS because of the high stability and consistency of the resulting SERS signal.
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页数:14
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