The usual Thomistic reading of the relationship between the natural sciences and theology speaks of the integrity and autonomy of nature and its science through the distinction between primary and secondary causality. Here theological reflection is not directly affected by the different scientific theories about the beginning and the end of the universe, as famously expounded by Abb & eacute; Lema & icirc;tre. I will try to outline some attempts to go beyond the Thomistic distinction, addressing the question of the end of the universe (the temporal question) and its purpose (the question. theological and moral), coherentist proposals of recent scientists -theologians, highlighting some difficulties in their positions. Then, we will move on to epistemological considerations on explanation, interpretation, and understanding in the natural and human sciences, highlighting theology as a science of lived faith. The main element of this experience is the stupor at the immensity of the universe, the enigma of a God who hides and reveals Himself there. This experience can only end in a doxology.