Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity

被引：0

作者：

Hu, Jiang ^{[1
,2
]}

Ji, Ren ^{[1
]}

Yang, Guang-Rong ^{[3
]}

Lv, Tao ^{[1
]}

Li, Qiang ^{[1
]}

Gao, Feng ^{[4
]}

机构：

[1] Qujing Normal Univ, Coll Biol Resources & Food Engn, Qujing 655011, Peoples R China

[2] Qujing Normal Univ, Yunnan Engn Res Ctr Fruit, Wine, Qujing 655011, Peoples R China

[3] Qujing Normal Univ, Coll Chem & Environm Sci, Qujing 655011, Peoples R China

[4] Gen Hosp Northern Theatre Command, Dept Endoscopy, Shenyang 110016, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2025年 / 27卷 / 02期

关键词：

Aconitum nagarum; Ranunculaceae; diterpenoid alkaloid; cytotoxic activity;

D O I：

10.1080/10286020.2024.2373326

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A chemical investigation on the roots of Aconitum nagarum afforded two undescribed C-19-diterpenoid alkaloids nagarumines D and E (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested in vitro for cytotoxic activity against five gastric tumor cell lines. Consequently, compound 2 exhibited some cytotoxicities against several human cancer cell lines with IC50 value less than 20.0 mu M.

引用

页码：169 / 175

页数：7

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