Performance of antisaccades in patients with cerebral small vessel disease accompanied by white matter hyperintensities

被引:0
作者
Fan, Huimin [1 ,2 ]
Feng, Jing [1 ,2 ]
Ding, Yuchuan [3 ,6 ]
Gu, Pan [1 ,2 ]
Wang, Liying [1 ,2 ]
Chen, Xiaomeng [1 ,2 ]
Geng, Xiaokun [1 ,2 ,3 ,4 ,5 ]
机构
[1] Capital Med Univ, Dept Neurol, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Luhe Hosp, Stroke Intervent & Translat Ctr SITC, Beijing, Peoples R China
[3] Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USA
[4] Capital Med Univ, Beijing Luhe Hosp, China Amer Inst Neurosci, Beijing, Peoples R China
[5] Capital Med Univ, Beijing Luhe Hosp, Stroke Ctr, Dept Neurol, 82 Xinhua SouthRd, Beijing 101149, Peoples R China
[6] Wayne State Univ, Sch Med, Dept Neurosurg, 550 E Canfield, Detroit, MI 48201 USA
关键词
Eye movements; cognitive functions; Montreal Cognitive Assessment (MoCA); Mini-Mental State Examination (MMSE); antisaccades; MINI-MENTAL-STATE; COGNITIVE CONTROL; TASK; DEMENTIA; NETWORK; TOOL;
D O I
10.1080/01616412.2024.2367934
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
ObjectivesThe antisaccades (AS) task is considered a reliable indicator of inhibitory control of eye movements in humans. Achieving good AS performance requires efficient cognitive processes that are sensitive to changes in brain structure. White matter hyperintensities (WMH) can cause subcortical-cortical dysconnectivity, affecting diverse cognitive domains. Thus, the AS task was investigated in patients with WMH in cerebral small vessel disease (CSVD).MethodsIn this retrospective study, 75 participants with WMH, determined by neuroimaging standards for CSVD research, were admitted to the Department of Neurology of Beijing Luhe Hospital, Capital Medical University from January 2021 to December 2022. All subjects underwent the AS task, Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and 3.0T brain MRI. Additionally, 61 healthy subjects were recruited to characterize WMH profiles.ResultsCompared to the control group, patients with WMH had a significantly increased AS error rate (49.81%, p = 0.001) and lower gain (76.00%, p = 0.042). The AS error rate was significantly higher in patients with WMH in the frontal lobe than in those without WMH (p = 0.004). After adjusting for confounders (age), a positive correlation was found between the AS error rate and MoCA scores for patients with WMH (coefficient = 0.262, p = 0.024).ConclusionsPatients with WMH due to CSVD exhibited abnormal AS performances, particularly in the frontal lobe. The eye movement paradigms, the new diagnostic forms in neurology, can be utilized to investigate the distributed cortical and subcortical systems involved in cognitive control processes, offering simple, well-tolerated and highly sensitive advantages over traditional measures.
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收藏
页码:917 / 924
页数:8
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