T-Cell Metabolic Reprogramming in Atherosclerosis

被引：1

作者：

Chang, Shuye ^{[1
]}

Wang, Zhaohui ^{[1
]}

An, Tianhui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Geriatr, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

来源：

BIOMEDICINES | 2024年 / 12卷 / 08期

基金：

中国国家自然科学基金;

关键词：

atherosclerosis; metabolic reprogramming; inflammations; T-cells; DIFFERENTIATION; AMPK; GLYCOLYSIS; RECEPTOR; PATHWAY; GLUCOSE; SERINE; MTOR;

D O I：

10.3390/biomedicines12081844

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis is a key pathological basis for cardiovascular diseases, significantly influenced by T-cell-mediated immune responses. T-cells differentiate into various subtypes, such as pro-inflammatory Th1/Th17 and anti-inflammatory Th2/Treg cells. The imbalance between these subtypes is critical for the progression of atherosclerosis (AS). Recent studies indicate that metabolic reprogramming within various microenvironments can shift T-cell differentiation towards pro-inflammatory or anti-inflammatory phenotypes, thus influencing AS progression. This review examines the roles of pro-inflammatory and anti-inflammatory T-cells in atherosclerosis, focusing on how their metabolic reprogramming regulates AS progression and the associated molecular mechanisms of mTOR and AMPK signaling pathways.

引用

页数：13

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