Seroprevalence of Measles and Rubella IgG Antibodies in Children and Pregnant Women in Iran

被引:1
作者
Tabatabaei, Sedigheh Rafiei [1 ]
Karimi, Abdollah [1 ]
Alebouyeh, Masoud [1 ]
Zahed, Ghazal [2 ]
Faghihian, Eliman [3 ]
Jefrideh, Yalda [4 ]
Azad, Talat Mokhtari [5 ]
Shamshiri, Ahmadreza [6 ]
Shariatpanahi, Ghazal [7 ]
机构
[1] Shahid Beheshti Univ Med Sci, Res Inst Childrens Hlth, Pediat Infect Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran
[3] Shahid Beheshti Univ Med Sci, Mofid Hosp, Tehran, Iran
[4] Iondishapoor Univ Med Sci, Dept Obstet & Gynecol, Ahvaz, Iran
[5] Univ Tehran Med Sci, Tehran, Iran
[6] Univ Tehran Med Sci, Res Ctr Caries Prevent, Dent Res Inst, Dept Community Oral Hlth,Sch Dent, Tehran, Iran
[7] Univ Tehran Med Sci, Bahrami Hosp, Tehran, Iran
来源
ARCHIVES OF PEDIATRIC INFECTIOUS DISEASES | 2024年 / 12卷 / 02期
关键词
Infant; Preschool Child; Antibodies; Measles; Pregnant women; Rubella; Vaccination;
D O I
10.5812/apid-140365
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Background: Complete immunization against Rubella and Measles (MR) in pediatrics is achieved using 2 doses of the Measles, Mumps, and Rubella-containing vaccine (MMR) in Iran at 12 and 18 months of age, where more than 95% of children under 5 years of age are vaccinated. Antibody waning in mothers and older children, and genetic diversity in immune responses may render them susceptible to infections. Objectives: This study aimed to investigate the diversity in immunoglobulin G (IgG) antibody levels against these two viruses in pregnant women, infants younger than 2 months, children at 6,12, and 18 months, and 5 - 6 years of age in Iran. Methods: This study was conducted on serum specimens sent to the National Reference Laboratory for Measles and Rubella in Tehran, Iran, from children under 2 months (n:50), 6 (n: 54),12 (n: 54), and 18 (n: 39) months, and 5 - 6 years old (n: 49), as well as women at 37 weeks of pregnancy (n: 53), from May to December 2020. Rubella and Measles-specific IgG were measured using an Results: Among serum samples from different provinces of Iran, the lowest positive level of Measles IgG was observed in children aged 6 and 12 months (7.41%), while the highest positive level was found in children aged 18 months (84.62%). For Rubella, the lowest IgG-positive level was seen in children aged 11 - 13 months (11.11%), while the highest positive level was observed in the 5 - 6 years old group (83.67%). Antibody levels against measles and rubella were higher in pregnant women than in children. Conclusions: Measles and Rubella antibody titers were lower in children 12 months before vaccination and reached a positive level in children aged 18 months post-vaccination. Whereas, lower Measles IgG levels in 5 - 6 years old children compared to 18 months old children may be due to waning antibodies. Pregnant women exhibited high levels of protection against these viruses (more than 80% had positive rubella IgG), as anticipated from outcomes of the national vaccination program in 2004.
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