Exploring the Comprehensive Neuroprotective and Anticancer Potential of Afzelin

被引：4

作者：

Kciuk, Mateusz ^{[1
]}

Garg, Nitika ^{[2
]}

Dhankhar, Sanchit ^{[2
]}

Saini, Monika ^{[3
,4
]}

Mujwar, Somdutt ^{[2
]}

Devi, Sushma ^{[2
]}

Chauhan, Samrat ^{[2
]}

Singh, Thakur Gurjeet ^{[2
]}

Singh, Randhir ^{[5
]}

Marciniak, Beata ^{[1
]}

Gielecinska, Adrianna ^{[1
,6
]}

Kontek, Renata ^{[1
]}

机构：

[1] Univ Lodz, Fac Biol & Environm Protect, Dept Mol Biotechnol & Genet, 12-16 Banacha St, PL-90237 Lodz, Poland

[2] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India

[3] Maharishi Markandeshwar Deemed Univ, M M Coll Pharm, Ambala 133207, Haryana, India

[4] Swami Vivekanand Coll Pharm, Banur 140601, Punjab, India

[5] Cent Univ Punjab, Dept Pharmacol, Bathinda 151401, Punjab, India

[6] Univ Lodz, Doctoral Sch Exact & Nat Sci, PL-90237 Lodz, Poland

来源：

PHARMACEUTICALS | 2024年 / 17卷 / 06期

基金：

英国科研创新办公室;

关键词：

afzelin; neurodegeneration; neuroinflammation; Alzheimer's disease; Parkinson's disease; cancer; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; ALZHEIMERS-DISEASE; COPAIFERA-LANGSDORFFII; PARKINSONS-DISEASE; THERAPEUTIC TARGET; HOUTTUYNIA-CORDATA; HEME OXYGENASE-1; FLAVONOIDS; MECHANISMS;

D O I：

10.3390/ph17060701

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, and others) and cancer, seemingly disparate in their etiology and manifestation, exhibit intriguing associations in certain cellular and molecular processes. Both cancer and neurodegenerative diseases involve the deregulation of cellular processes such as apoptosis, proliferation, and DNA repair and pose a significant global health challenge. Afzelin (kaempferol 3-O-rhamnoside) is a flavonoid compound abundant in various plant sources. Afzelin exhibits a diverse range of biological activities, offering promising prospects for the treatment of diseases hallmarked by oxidative stress and deregulation of cell death pathways. Its protective potential against oxidative stress is also promising for alleviating the side effects of chemotherapy. This review explores the potential therapeutic implications of afzelin, including its capacity to mitigate oxidative stress, modulate inflammation, and promote cellular regeneration in neurodegenerative and cancer diseases.

引用

页数：21

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