Copper-Catalyzed [3+2] Annulation of O-Acyl Oximes with 4-Sulfonamidophenols for the Synthesis of 5-Sulfonamidoindoles and 2-Amido-5-sulfonamidobenzofuran-3(2H)-ones

被引：5

作者：

Hu, Zi-Jun ^{[1
]}

Chen, Wei ^{[2
]}

Lyu, Xinyu ^{[1
]}

Zhang, Hui-Peng ^{[1
]}

Chen, Si-Wei ^{[1
]}

Ding, Xian-Heng ^{[1
]}

Yu, Cang-Hai ^{[1
]}

Cui, Zhen ^{[1
]}

Miao, Chun-Bao ^{[1
]}

Yang, Hai-Tao ^{[1
]}

机构：

[1] Changzhou Univ, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Jiangsu, Peoples R China

[2] Changzhou Siyao Pharmaceut Co Ltd, Changzhou 213018, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 20期

关键词：

INDOLES; ACID;

D O I：

10.1021/acs.orglett.4c01071

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed [3 + 2] annulation of O-acyl oximes with 4-sulfonamidophenols is developed. The advantage of this method lies in the concurrent double activation of two substrates to form nucleophilic enamines and electrophilic quinone monoimines. The substituent on the alpha-carbon of O-acyl oxime determines two different reaction pathways, thereby leading to the selective generation of 5-sulfonamidoindoles and 2-amido-5-sulfonamidobenzofuran-3(2H)-ones.

引用

页码：4229 / 4234

页数：6

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