The aetiology of pouchitis in patients with inflammatory bowel disease

被引：3

作者：

Alenzi, Maram ^{[1
]}

Schildkraut, Tamar ^{[2
]}

Hartley, Imogen ^{[2
,3
]}

Badiani, Sarit ^{[4
]}

Ding, Nik Sheng ^{[2
,3
]}

Rao, Vikram ^{[5
]}

Segal, Jonathan P. ^{[3
,6
]}

机构：

[1] Harvard Med Sch, Dept Med, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02115 USA

[2] St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia

[3] Royal Melbourne Hosp, Dept Gastroenterol, Parkville, Vic, Australia

[4] Royal North Shore Hosp, Dept Surg, St Leonards, NSW, Australia

[5] Western Hlth, Dept Gen Med, Footscray, Vic, Australia

[6] Univ Melbourne, Dept Med, Parkville, Vic, Australia

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2024年 / 17卷

关键词：

IBD; pouchitis; ulcerative colitis; ANTINEUTROPHIL CYTOPLASMIC ANTIBODY; ULCERATIVE-COLITIS PATIENTS; FAMILIAL ADENOMATOUS POLYPOSIS; SULFATE-REDUCING BACTERIA; IL-1 RECEPTOR ANTAGONIST; ILEAL-POUCH; ANAL ANASTOMOSIS; RESTORATIVE PROCTOCOLECTOMY; HYDROGEN-SULFIDE; CROHNS-DISEASE;

D O I：

10.1177/17562848241249449

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Restorative proctocolectomy with ileal pouch-anal anastomosis is a treatment option for patients with refractory ulcerative colitis. Pouchitis is the most common complication, representing a spectrum of diseases ranging from acute antibiotic-responsive type to chronic antibiotic-refractory. Early accurate diagnosis using a combined assessment of symptoms, endoscopy and histology is important for both treatment and prognostication. Most patients respond well to antibiotic therapy; however, management of chronic antibiotic-refractory pouchitis remains a challenge, and treatment options are based on small studies. Pouchitis is thought to be driven by the interaction between genetics, the immune system and the environment but as yet a causal relationship has yet to be identified. Further longitudinal assessment of the pouch integrating new technologies may help us understand the factors driving pouchitis. This review outlines the currently understood risk factors and aetiology of pouchitis.

引用

页数：15

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