Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway

被引：5
作者：
Ma, Zelong [1 ]
Zhou, Faxiao [1 ]
Jin, Hua [1 ]
Wu, Xiaoming [1 ]
机构：
[1] Kunming Univ Sci & Technol, Med Sch, Lab Mol Genet Aging & Tumor, Chenggong Campus,727 South Jingming Rd, Kunming 650500, Peoples R China
来源：
CELLS | 2024年 / 13卷 / 12期
关键词：
CXCL12/CXCR4/ACKR3; axis; STAT3 signaling pathway; targeted therapy; JAK2; IL6; EPITHELIAL-MESENCHYMAL TRANSITION; NEGATIVE MAMMARY CARCINOGENESIS; HUMAN HEPATOCELLULAR-CARCINOMA; CDDO-METHYL ESTER; DOWN-REGULATION; GASTRIC-CANCER; TYROSINE PHOSPHORYLATION; TRANSCRIPTION FACTORS; ADENOCARCINOMA CELLS; PROTEIN INHIBITOR;
D O I：
10.3390/cells13121027
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple mechanisms, while the STAT3 pathway also regulates the expression of CXCL12. This review offers a thorough and systematic analysis of the reciprocal regulatory mechanisms between the CXCL12/CXCR4/ACKR3 signaling axis and the STAT3 signaling pathway in the context of diseases, particularly tumors. It explores the potential clinical applications in tumor treatment, highlighting possible therapeutic targets and novel strategies for targeted tumor therapy.
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页数：22
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