Pembrolizumab-induced asthma exacerbation with hypereosinophilia and elevated interleukin-5 in endometrial cancer: A case report

被引：1

作者：

Harada, Tomoya ^{[1
]}

Uetani, Naoki ^{[1
]}

Inui, Genki ^{[1
]}

Ishikawa, Hiroki ^{[1
]}

Funaki, Yoshihiro ^{[1
]}

Takata, Miki ^{[1
]}

Okazaki, Ryota ^{[1
]}

Yamaguchi, Kosuke ^{[1
]}

Morita, Masato ^{[1
]}

Kitatani, Shin ^{[2
]}

Yamasaki, Akira ^{[1
]}

机构：

[1] Tottori Univ, Fac Med, Div Resp Med & Rheumatol, 36-1 Nishi Cho, Yonago, Tottori, Japan

[2] Tottori Prefectural Kousei Hosp, Dept Respirol, Tottori, Japan

来源：

RESPIRATORY MEDICINE CASE REPORTS | 2024年 / 49卷

关键词：

Asthma; Eosinophil; Immune checkpoint inhibitor; Immune-related adverse events; Pembrolizumab; PATIENT;

D O I：

10.1016/j.rmcr.2024.102035

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Pembrolizumab is an anti-programmed cell death-1 (PD-1) antibody used to treat various cancer types. Treatments with such immune checkpoint inhibitors cause immune-related adverse events. However, airway inflammation caused by immune-related adverse events has rarely been reported. A 54-year-old woman with endometrial cancer experienced asthma exacerbation, and increased blood eosinophil counts 3 months after pembrolizumab administration. Although asthma exacerbation improved, the resumption of pembrolizumab caused the recurrence of dry cough and hypereosinophilia. The discontinuation of pembrolizumab improved her symptoms. Serum interleukin-5 levels increased during pembrolizumab treatment but decreased upon discontinuation. The blockade of PD-1 and its ligand may exacerbate asthma through eosinophilic inflammation.

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