Advances in the application of iron oxide nanoparticles (IONs and SPIONs) in three-dimensional cell culture systems

被引:1
作者
Aye, Khin The Nu [1 ]
Ferreira, Joao N. [1 ]
Chaweewannakorn, Chayanit [1 ,2 ]
Souza, Glauco R. [3 ]
机构
[1] Chulalongkorn Univ, Fac Dent, Dept Res Affairs, Avatar Biotechnol Oral Hlth & Hlth Longev Res Unit, Bangkok, Thailand
[2] Chulalongkorn Univ, Fac Dent, Dept Occlus, Bangkok, Thailand
[3] Greiner Bio One North Amer Inc, 4238 Capital Dr, Monroe, NC 28110 USA
来源
SLAS TECHNOLOGY | 2024年 / 29卷 / 03期
关键词
Iron oxide nanoparticles; Magnetic nanoparticles; 3D cell culture; Magnetic bioprinting; Tissue engineering; IN-VITRO; GOLD NANOPARTICLES; COCULTURE MODEL; SIZE; CYTOTOXICITY; TOXICITY; SURFACE; GENERATION; ORGANOIDS;
D O I
10.1016/j.slast.2024.100132
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Background: The field of tissue engineering has remarkably progressed through the integration of nanotechnology and the widespread use of magnetic nanoparticles. These nanoparticles have resulted in innovative methods for three-dimensional (3D) cell culture platforms, including the generation of spheroids, organoids, and tissuemimetic cultures, where they play a pivotal role. Notably, iron oxide nanoparticles and superparamagnetic iron oxide nanoparticles have emerged as indispensable tools for non-contact manipulation of cells within these 3D environments. The variety and modification of the physical and chemical properties of magnetic nanoparticles have profound impacts on cellular mechanisms, metabolic processes, and overall biological function. This review article focuses on the applications of magnetic nanoparticles, elucidating their advantages and potential pitfalls when integrated into 3D cell culture systems. This review aims to shed light on the transformative potential of magnetic nanoparticles in terms of tissue engineering and their capacity to improve the cultivation and manipulation of cells in 3D environments.
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页数:9
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