Computational modelling of mouse atrio ventricular node action potential and automaticity

被引：4

作者：

Bartolucci, Chiara ^{[1
]}

Mesirca, Pietro ^{[2
,3
]}

Ricci, Eugenio ^{[1
]}

Sales-Belles, Clara ^{[4
]}

Torre, Eleonora ^{[2
,3
]}

Louradour, Julien ^{[2
,3
]}

Mangoni, Matteo Elia ^{[2
,3
]}

Severi, Stefano ^{[1
]}

机构：

[1] Univ Bologna, Dept Elect Elect & Informat Engn Guglielmo Marconi, Computat Physiopathol Unit, Cesena, Italy

[2] Univ Montpellier, CNRS, INSERM, Inst Genomique Fonct, Montpellier, France

[3] LabEx Ion Channels Sci & Therapeut ICST, Montpellier, France

[4] Univ Zaragoza, Inst I3A, BSICoS Grp, IIS Aragon, Zaragoza, Spain

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2024年 / 602卷 / 19期

关键词：

atrio-ventricular node; action potential; cardiac electrophysiology; cardiomyocyte; computer simulation; ion channels; mouse; pacemaker activity; ATRIOVENTRICULAR NODE; SINOATRIAL NODE; ELECTROPHYSIOLOGICAL PROPERTIES; MATHEMATICAL-MODEL; PACEMAKER ACTIVITY; CELLS; RYANODINE; CHANNELS; POPULATIONS; CONDUCTION;

D O I：

10.1113/JP285950

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

figure legend The abstract figure illustrates the process of creating and validating a new numerical model for a single atrioventricular node (AVN) cell. The steps are as follows: (1) cells from the AVN were isolated from the mice hearts; (2) they underwent patch-clamp experiments to measure the L-type calcium current (ICav1.3); (3) experimental data and the new numerical model were fitted to generate the I-V (current-voltage) relationship; (4) the new numerical model was built incorporating various ionic currents and was able to simulate the electrical activity (membrane potential, Vm) and intracellular calcium dynamics (Cai) in the AVN cells; (5) the model was validated by comparing simulated action potentials and calcium transients under control conditions and after currents block and by generating a population of AVN models. image

引用

页码：4821 / 4847

页数：27

共 41 条

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