Immunotherapy for HPV negative head and neck squamous cell carcinoma

被引：3

作者：

Jiang, Binyumeng ^{[1
]}

Elkashif, Ahmed ^{[1
]}

Coulter, Jonathan A. ^{[1
]}

Dunne, Nicholas J. ^{[2
]}

Mccarthy, Helen O. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, North Ireland

[2] Dublin City Univ, Sch Mech & Mfg Engn, Dublin, Ireland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2024年 / 1879卷 / 05期

关键词：

HNSCC; Vaccines; mRNA; Immunotherapy; T; -cells; Dendritic cells; PHASE-I; DENDRITIC CELLS; T-CELLS; PEPTIDE VACCINE; CANCER VACCINE; TP53; MUTATIONS; COMBINATION; ANTIGEN; PROTEIN; TRIAL;

D O I：

10.1016/j.bbcan.2024.189138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Head and neck cancer (HNSCC) is the 8th most common cancer in the UK, with incidence increasing due to lifestyle factors such as tobacco and alcohol abuse. HNSCC is an immune-suppressive disease characterised by impaired cytokine secretion and dysregulation of immune infiltrate. As such, immunotherapy is a potential treatment option, with therapeutic cancer vaccination demonstrating the greatest potential. The success of cancer vaccination is dependent on informed antigen selection: an ideal antigen must be either tumour-specific or tumour-associated, as well as highly immunogenic. Stratification of the patient population for antigen expression and validated biomarkers are also vital. This review focuses on the latest developments in immunotherapy, specifically the development of therapeutic vaccines, and highlights successes, potential drawbacks and areas for future development. Immunotherapy approaches considered for HNSCC include monoclonal antibodies (mAb), Oncolytic viral (OV) therapies, Immune Checkpoint Inhibitors (ICIs) and cancer vaccines.

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