Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes

被引:3
作者
Yu, Qingyuan [1 ]
Xiao, Yanan [1 ]
Guan, Mengqi [1 ]
Zhang, Xianshuai [1 ]
Yu, Jianan [1 ]
Han, Mingze [1 ]
Li, Zhenhua [2 ]
机构
[1] Changchun Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changchun, Peoples R China
[2] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Orthoped Ctr, Changchun, Peoples R China
关键词
ferroptosis; copper homeostasis; oxidative stress; osteoarthritis; chondrocytes; dual regulation; cuproptosis ferroptosis; cuproptosis; MESOPOROUS BIOACTIVE GLASS; HEALTH-RISK ASSESSMENT; P-TYPE ATPASE; TRACE-ELEMENTS; SUPEROXIDE-DISMUTASE; ARTICULAR-CARTILAGE; POTENTIAL TOXICITY; BONE REGENERATION; TRANSITION-METALS; IRON ACCUMULATION;
D O I
10.3389/fmolb.2024.1472492
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss. Emerging evidence indicates that chondrocyte ferroptosis plays a role in OA development. However, most research has concentrated on ferroptosis regulation involving typical iron ions, potentially neglecting the significance of elevated copper ions in both serum and joint fluid of patients with OA. This review aims to fill this gap by systematically examining the interplay between copper metabolism, oxidative stress, ferroptosis, and copper-associated cell death in OA. It will provide a comprehensive overview of copper ions' role in regulating ferroptosis and their dual role in OA. This approach seeks to offer new insights for further research, prevention, and treatment of OA.
引用
收藏
页数:20
相关论文
共 287 条
  • [11] Affinity gradients drive copper to cellular destinations
    Banci, Lucia
    Bertini, Ivano
    Ciofi-Baffoni, Simone
    Kozyreva, Tatiana
    Zovo, Kairit
    Palumaa, Peep
    [J]. NATURE, 2010, 465 (7298) : 645 - U145
  • [12] Hepatic copper-transporting ATPase ATP7B: function and inactivation at the molecular and cellular level
    Bartee, Mee Y.
    Lutsenko, Svetlana
    [J]. BIOMETALS, 2007, 20 (3-4) : 627 - 637
  • [13] Changes of trace element status during aging: results of the EPIC-Potsdam cohort study
    Baudry, Julia
    Kopp, Johannes F.
    Boeing, Heiner
    Kipp, Anna P.
    Schwerdtle, Tanja
    Schulze, Matthias B.
    [J]. EUROPEAN JOURNAL OF NUTRITION, 2020, 59 (07) : 3045 - 3058
  • [14] Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
    Beaino, Wissam
    Guo, Yunjun
    Chang, Albert J.
    Anderson, Carolyn J.
    [J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 19 (03): : 427 - 438
  • [15] Copper(II) Complexes with Carnosine Conjugates of Hyaluronic Acids at Different Dipeptide Loading Percentages Behave as Multiple SOD Mimics and Stimulate Nrf2 Translocation and Antioxidant Response in In Vitro Inflammatory Model
    Bellia, Francesco
    Lanza, Valeria
    Naletova, Irina
    Tomasello, Barbara
    Ciaffaglione, Valeria
    Greco, Valentina
    Sciuto, Sebastiano
    Amico, Pietro
    Inturri, Rosanna
    Vaccaro, Susanna
    Campagna, Tiziana
    Attanasio, Francesco
    Tabbi, Giovanni
    Rizzarelli, Enrico
    [J]. ANTIOXIDANTS, 2023, 12 (08)
  • [16] Massive copper and selenium losses cause life-threatening deficiencies during prolonged continuous renal replacement
    Ben-Hamouda, Nawfel
    Charriere, Melanie
    Voirol, Pierre
    Berger, Mette M.
    [J]. NUTRITION, 2017, 34 : 71 - 75
  • [17] Influence of Cu2+ on Osteoclast Formation and Activity In Vitro
    Bernhardt, Anne
    Bacova, Jana
    Gbureck, Uwe
    Gelinsky, Michael
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (05) : 1 - 14
  • [18] The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
    Bersuker, Kirill
    Hendricks, Joseph M.
    Li, Zhipeng
    Magtanong, Leslie
    Ford, Breanna
    Tang, Peter H.
    Roberts, Melissa A.
    Tong, Bingqi
    Maimone, Thomas J.
    Zoncu, Roberto
    Bassik, Michael C.
    Nomura, Daniel K.
    Dixon, Scott J.
    Olzmann, James A.
    [J]. NATURE, 2019, 575 (7784) : 688 - +
  • [19] Efficacy of vitamin E in knee osteoarthritis management of North Indian geriatric population
    Bhattacharya, Ijen
    Saxena, Rahul
    Gupta, Veena
    [J]. THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE, 2012, 4 (01) : 11 - 19