Erythema nodosum following COVID-19 vaccination: A case report and literature review

There have been a few reported cases of erythema nodosum (EN) after coronavirus disease 2019 (COVID-19) vaccination. A 48-year-old healthy woman was referred to our department with multiple erythematous nodules of varying sizes on her extremities 10 days after receiving the third COVID-19 vaccine dose. The clinical and pathological findings of the patients were consistent with EN. We reviewed 18 EN cases post-COVID-19 vaccination. Considering the low number of reported EN cases, a causal link between EN and COVID-19 vaccination is still under debate. Erythema nodosum (EN) is the most common form of panniculitis and is characterized by tender erythematous nodules. Few cases of EN after COVID-19 vaccination have been reported. In this letter, we report a case of EN after COVID-19 vaccination. Since we're implementing the questionnaire survey of adverse events with COVID-19 vaccination as a set, almost all adverse events have been grasped in detail. Nevertheless, the number of reported cases of EN is considerably low compared with the number of COVID-19 vaccine administrations. image