Effect of Andrographis Paniculata Aqueous Extract on Hyperammonemia Induced Alteration of Oxidative and Nitrosative Stress Factors in the Liver, Spleen and Kidney of Rats

被引:0
作者
Mukherjee, Arghya [1 ]
Singh, Vineet Prakash [2 ]
Singh, Santosh [1 ]
机构
[1] Guru Ghasidas Vishwavidyalaya Cent Univ, Dept Zool, Biochem & Mol Biol Lab, Bilaspur 495009, Chhattisgarh, India
[2] Govt India, Govt Coll UT Adm DNH & DD, Dept Zool, Daman, India
关键词
Hyperammonemia (HA); Hepatic encephalopathy (HE); oxidative stress; antioxidant enzymes; CEREBRAL-CORTEX; NITRIC-OXIDE; BRAIN; ENCEPHALOPATHY; PATHOGENESIS;
D O I
10.1080/10496475.2024.2370968
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Hyperammonemia (HA) can induce oxidative and nitrosative stress in peripheral organs, potentially exacerbating Hepatic Encephalopathy (HE). This study assessed the efficacy of Andrographis paniculata aqueous extract (APAE) in mitigating oxidative and nitrosative stress caused by non-cirrhotic HA in rat livers, spleens, and kidneys. HA was induced via intraperitoneal injection of ammonium acetate, while APAE was administered orally. The study measured malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and glutathione reductase (GR) to gauge oxidative stress, and nitric oxide (NO) levels as a marker of nitrosative stress. Both acute and chronic HA altered the levels of antioxidant enzymes, MDA, and NO in the organs studied. APAE treatment helped restore SOD, catalase, and GR levels, and decreased MDA and NO levels, demonstrating its potential in reducing oxidative stress linked to HA in the liver, spleen, and kidney.
引用
收藏
页码:413 / 428
页数:16
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