PWP1 is overexpressed in hepatocellular carcinoma and facilitates liver cancer cell proliferation

被引：2

作者：

Huang, Rong ^{[1
]}

Xu, Fu ^{[1
]}

Su, Luying ^{[1
]}

Lu, Yan ^{[1
]}

Liu, Wei ^{[1
]}

Liu, Shuaihu ^{[1
]}

Yang, Ling ^{[2
]}

Su, Liya ^{[2
]}

Song, Wei ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Sch Basic Med, Dept Biochem & Mol Biol,Peking Union Med Coll, State Key Lab Common Mech Res Major Dis,Inst Basic, Beijing 100005, Peoples R China

[2] Inner Mongolia Med Univ, Clin Med Res Ctr, Affiliated Hosp, Inner Mongolia Key Lab Med Cell Biol, 1 Tong Dao St, Hohhot 010050, Inner Mongolia, Peoples R China

来源：

HELIYON | 2024年 / 10卷 / 11期

关键词：

Hepatocellular carcinoma (HCC); Periodic tryptophan protein 1 (PWP1); Tumorigenesis; Therapeutic target; MICROARRAY DATA; SURVIVAL; GENE; PROTEIN; TOOL; EXPRESSION; CHROMATIN; FAMILY;

D O I：

10.1016/j.heliyon.2024.e32409

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Identification of novel biomarkers for prediction of disease course and prognosis is needed to reduce morbidity of liver hepatocellular carcinoma (LIHC/HCC) patients. Although dysregulated Periodic tryptophan protein 1 homolog (PWP1/endonuclein) expression has been detected in several tumors, the potential regulatory effect of PWP1 on LIHC remains uncertain. Here we evaluated the expression of PWP1 using multiple online platforms, and demonstrated that PWP1 upregulation was consistently observed in LIHC relative to non-tumor liver tissues and correlated with unfavorable prognosis. Moreover, HCC prognosis was significantly influenced by the methylation status of various CpG sites in the PWP1 gene. Lastly, we provide direct evidence that PWP1 acts as a driver of HCC progression by showing that siRNA-mediated PWP1 silencing significantly suppressed HCC cell proliferation in vitro. These data strongly suggest that PWP1 silencing may be an effective therapeutic strategy to treat LIHC.

引用

页数：13

共 29 条

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