Functionally Designed Nanovaccines against SARS-CoV-2 and Its Variants

被引：1

作者：

Xi, Yue ^{[1
,2
]}

Ma, Rongrong ^{[1
,2
,3
]}

Li, Shuo ^{[1
,2
,3
]}

Liu, Gang ^{[2
,3
,4
]}

Liu, Chao ^{[1
,2
,5
]}

机构：

[1] Xiamen Univ, State Key Lab Stress Biol, Xiamen 361102, Peoples R China

[2] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China

[3] Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China

[4] Xiamen Univ, Innovat Ctr Cell Biol, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China

[5] Xiamen Univ, China Shenzhen Res Inst, Shenzhen 518000, Peoples R China

来源：

VACCINES | 2024年 / 12卷 / 07期

基金：

中国国家自然科学基金;

关键词：

nanovaccines; SARS-CoV-2; functionalization; VACCINE; NANOPARTICLES; COVID-19; DELIVERY; SAFETY; EFFICACY; PHASE-3;

D O I：

10.3390/vaccines12070764

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

COVID-19, generated by SARS-CoV-2, has significantly affected healthcare systems worldwide. The epidemic has highlighted the urgent need for vaccine development. Besides the conventional vaccination models, which include live-attenuated, recombinant protein, and inactivated vaccines, nanovaccines present a distinct opportunity to progress vaccine research and offer convenient alternatives. This review highlights the many widely used nanoparticle vaccine vectors, outlines their benefits and drawbacks, and examines recent developments in nanoparticle vaccines to prevent SARS-CoV-2. It also offers a thorough overview of the many advantages of nanoparticle vaccines, including an enhanced host immune response, multivalent antigen delivery, and efficient drug delivery. The main objective is to provide a reference for the development of innovative antiviral vaccines.

引用

页数：18

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