Programmed cell death in autoimmune diseases ferroptosis

被引：7

作者：

Sun, Jiantao ^{[1
]}

Huang, Lujuan ^{[1
]}

Wang, Jiawei ^{[1
]}

Hu, Yelang ^{[2
]}

Wang, Wenmin ^{[2
]}

Zhu, Haihong ^{[1
]}

机构：

[1] Haining Kanghua Hosp, Rheumatol & Immunol Dept, 2299 Jiangnan Ave, Jiaxing, Peoples R China

[2] Biol Med Res & Dev Ctr, Yangtze Delta Zhejiang, Hangzhou, Peoples R China

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2024年 / 82卷 / 01期

关键词：

ferroptosis; autoimmune diseases; systemic lupus erythematosus; rheumatoid arthritis; multiple sclerosis; ankylosing spondylitis; ANKYLOSING-SPONDYLITIS; OXIDATIVE STRESS; IRON;

D O I：

10.1684/abc.2024.1866

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Ferroptosis is an iron dependent cell death driven by lipid peroxidation. Over the past decade, increasing evidence has confirmed that ferroptosis plays an irreplaceable role in the occurrence and development of many diseases, including various cancers, neurodegenerative diseases, cardiovascular diseases and autoimmune diseases. Autoimmune disease is an inflammatory disease characterized by the breakdown of immune tolerance. Nowadays, accumulating evidence indicates that ferroptosis is closely related to the pathogenesis of autoimmune diseases. Therefore, this review briefly introduced the mechanism of ferroptosis, and focused on the related research of ferroptosis in multiple autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), ankylosing spondylitis (AS). In addition, we also presented the idea of targeting ferroptosis as a potential therapeutic target for patients with autoimmune diseases, which may provide a direction for the development of new therapeutic strategies.

引用

页码：33 / 42

页数：10

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