The deregulation of arachidonic acid metabolism in ovarian cancer

被引：1
作者：
Xia, Qiuyi [1 ]
Gao, Wen [2 ]
Yang, Jintao [3 ]
Xing, Zhifang [1 ]
Ji, Zhaodong [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Lab Med, Shanghai, Peoples R China
[2] Univ Chinese Acad Sci, Zhejiang Canc Hosp, Inst Basic Med & Canc IBMC, Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou, Zhejiang, Peoples R China
[3] Key Lab Digital Technol Med Diagnost Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
arachidonic acid; ovarian cancer; metabolic pathway; biological marker; targeted therapy; ACTIVATED-RECEPTOR-GAMMA; CELL-PROLIFERATION; TNF-ALPHA; KAPPA-B; COX-2; EXPRESSION; PATHWAY; 5-LIPOXYGENASE; ADENOCARCINOMA; ANGIOGENESIS;
D O I：
10.3389/fonc.2024.1381894
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Arachidonic acid (AA) is a crucial polyunsaturated fatty acid in the human body, metabolized through the pathways of COX, LOX, and cytochrome P450 oxidase to generate various metabolites. Recent studies have indicated that AA and its metabolites play significant regulatory roles in the onset and progression of ovarian cancer. This article examines the recent research advancements on the correlation between AA metabolites and ovarian cancer, both domestically and internationally, suggesting their potential use as biological markers for early diagnosis, targeted therapy, and prognosis monitoring.
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页数：10
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