Role of HLA-G in tumors and upon COVID-19 infection

被引：2
|
作者：
Seliger, Barbara [1 ,2 ,3 ]
机构：
[1] Med Sch Theodor Fontane, Inst Translat Immunol, D-14770 Brandenburg, Germany
[2] Martin Luther Univ Halle Wittenberg, Med Fac, Magdeburger Str 2, D-06112 Halle, Saale, Germany
[3] Fraunhofer Inst Cell Therapy & Immunol, D-04103 Leipzig, Germany
来源：
HUMAN IMMUNOLOGY | 2024年 / 85卷 / 03期
关键词：
HLA-G; Tumor; Virus; Regulation; Immune response; LEUKOCYTE ANTIGEN-G; G GENE-EXPRESSION; CELL CARCINOMA; UP-REGULATION; G ISOFORMS; NK; POLYMORPHISMS; MACROPHAGES; MICRORNAS; CANCER;
D O I：
10.1016/j.humimm.2024.110792
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
HLA-G expression of tumors and upon viral infections is involved in their immune escape leading to the evasion from both T and NK cell recognition. The underlying mechanisms of HLA-G expression in both pathophysiologic conditions are broad and range from genetic abnormalities to epigenetic, transcriptional and posttranscriptional regulation. This review summarizes the current knowledge of the frequency, regulation and clinical relevance of HLA-G expression upon neoplastic and viral transformation, its interaction with components of the microenvironment as well as its potential as diagnostic marker and/or therapeutic target. In addition, it discusses urgent topics, which have to be addressed in HLA-G research.
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页数：6
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