Characterization and Pathogenicity of the Novel Porcine Reproductive and Respiratory Syndrome Virus 1 Strain SL-01 in China

被引:1
作者
Zheng, Jiaying [1 ,2 ]
Wu, Yu [3 ]
Gao, Xiaopeng [1 ,2 ]
Lin, Limiao [4 ]
Chang, Hao [1 ,2 ]
Zhu, Guojun [4 ]
Fang, Siyun [4 ]
Li, Wei [4 ]
Ren, Bohua [4 ]
Li, Qunhui [4 ]
Zhang, Xiangbin [1 ,2 ]
机构
[1] South China Agr Univ, Coll Anim Sci, Guangzhou 510642, Peoples R China
[2] Guangdong Prov Key Lab Agroanim Genom & Mol Breedi, Guangzhou 510642, Peoples R China
[3] Sun Yat Sen Univ, Guangzhou Higher Educ Mega Ctr, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510000, Peoples R China
[4] Wens Food Grp, Yunfu 527400, Peoples R China
关键词
GENETIC DIVERSITY; GENOMIC CHARACTERIZATION; PRRSV; PROTEINS; ISOLATE;
D O I
10.1155/2024/6873468
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Currently, PRRSV-1 causes a large number of clinical infections in Chinese swine herds, and the prevalence of new strains has presented great challenges. In this study, the novel PRRSV-1 strain SL-01 was isolated, with a genome length of 14,978 bp, and genetic evolution analysis revealed that it belonged to a new subtype branch. Sequence homology analysis showed that the strain was only 82.2%-86.7% identical to the current classical PRRSV-1 strains. In particular, the novel strain exhibited a unique deletion pattern in Nsp2. In addition, GP3 and GP4 of the SL-01 strain showed four consecutive amino acid deletions in the highly variable regions at amino acids 243-248 and 63-68, respectively. Further challenges in piglet and pregnant sow demonstrated that the SL-01 strain could cause the piglet fever and death but less pathogenic to pregnant sow. Overall, the characterization and pathogenicity of a novel PRRSV-1 strain were first explored and provide a prevention for pig farms.
引用
收藏
页数:11
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