Role of Antitroponin Antibodies and Macrotroponin in the Clinical Interpretation of Cardiac Troponin

被引：7

作者：

Salaun, Erwan ^{[1
]}

Drory, Samuel ^{[1
]}

Cote, Marc-Andre ^{[1
]}

Tremblay, Veronic ^{[1
]}

Bedard, Elisabeth ^{[1
]}

Steinberg, Christian ^{[1
]}

Pare, David ^{[1
]}

O'Connor, Kim ^{[1
]}

Cieza, Tomas ^{[1
]}

Cote, Nancy ^{[1
]}

Poirier, Paul ^{[1
,3
]}

Douville, Pierre ^{[1
,2
]}

Blais, Jonatan ^{[2
]}

Desmeules, Philippe ^{[2
]}

Kalavrouziotis, Dimitris ^{[1
]}

Mohammadi, Siamak ^{[1
]}

Voisine, Pierre ^{[1
,4
]}

Bernier, Mathieu ^{[1
]}

Pibarot, Philippe ^{[1
]}

Theriault, Sebastien ^{[1
]}

机构：

[1] Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada

[2] Univ Laval, Ctr Hosp Univ Quebec, Quebec City, PQ, Canada

[3] Univ Laval, Fac Pharm, Quebec City, PQ, Canada

[4] Univ Ottawa, Div Cardiac Surg, Heart Inst, Ottawa, ON, Canada

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2024年 / 13卷 / 12期

关键词：

antitroponin antibodies; biomarker; cardiac troponin; macrotroponin; myocardial infarction; myocardial injury; myocarditis; ACUTE CORONARY SYNDROME; BIOTIN INTERFERENCE; HEART-FAILURE; T ASSAY; AUTOANTIBODIES; RELEASE; SKELETAL; BIOMARKERS; ELEVATION; DISEASE;

D O I：

10.1161/JAHA.123.035128

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac troponin is extensively used as a biomarker in modern medicine due to its diagnostic capability for myocardial injury, as well as its predictive and prognostic value for cardiac diseases. However, heterophile antibodies, antitroponin antibodies, and macrotroponin complexes can be observed both in seemingly healthy individuals and patients with cardiac diseases, potentially leading to false positive or disproportionate elevation of cTn (cardiac troponin) assay results and introducing discrepancies in clinical interpretations with impact on medical management. In this review article, we describe the possible mechanisms of cTn release and the sources of variations in the assessment of circulating cTn levels. We also explore the pathophysiological mechanisms underlying antitroponin antibody development and discuss the influence exerted by macrotroponin complexes on the results of immunoassays. Additionally, we explore approaches to detect these complexes by presenting various clinical scenarios encountered in routine clinical practice. Finally, unsolved questions about the development, prevalence, and clinical significance of cardiac autoantibodies are discussed.

引用

页数：16

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