Glutathione and acid dual-responsive bismuth-based nanosensitizer for chemo-mediated cancer sonodynamic therapy

被引:0
作者
Chen, Guobo [1 ,2 ]
Ping, Jing [2 ]
Du, Jun [2 ]
Zhao, Linghao [1 ]
Li, Yuhao [2 ]
Liu, Hui [1 ]
机构
[1] Naval Med Univ, Shanghai Eastern Hepatobiliary Surg Hosp, Dept Nutr, Shanghai 200438, Peoples R China
[2] Univ Shanghai Sci & Technol, Inst Bismuth Sci, Sch Mat & Chem, Shanghai 200093, Peoples R China
基金
上海市自然科学基金; 中国国家自然科学基金;
关键词
bismuth heterojunction; sonodynamic therapy; chemotherapy; synergistic therapy;
D O I
10.1088/1748-605X/ad565c
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Chemotherapeutic agents hold significant clinical potential in combating tumors. However, delivering these drugs to the tumor site for controlled release remains a crucial challenge. In this study, we synthesize and construct a glutathione (GSH) and acid dual-responsive bismuth-based nano-delivery platform (BOD), aiming for sonodynamic enhancement of docetaxel (DTX)-mediated tumor therapy. The bismuth nanomaterial can generate multiple reactive oxygen species under ultrasound stimulation. Furthermore, the loading of DTX to form BOD effectively reduces the toxicity of DTX in the bloodstream, ensuring its cytotoxic effect is predominantly exerted at the tumor site. DTX can be well released in high expression of GSH and acidic tumor microenvironment. Meanwhile, ultrasound can also promote the release of DTX. Results from both in vitro and in vivo experiments substantiate that the synergistic therapy involving chemotherapy and sonodynamic therapy significantly inhibits the growth and proliferation of tumor cells. This study provides a favorable paradigm for developing a synergistic tumor treatment platform for tumor microenvironment response and ultrasound-promoted drug release.
引用
收藏
页数:11
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