Design, Synthesis and Anticancer Evaluation of Benzoxazole Resemble Substituted Arylamide Derivatives of Bis-1,3,4-Oxadiazole-oxazolo[4,5-b]pyridin-2-yl) as Anticancer Agents

被引：0
|
作者：
Syeda, Arshiya Banu [1 ]
Syeda, Asra Banu [2 ]
Ferazoddin, Mohammad [1 ]
Rajeswari, M. [3 ]
Paul, J. P. [1 ]
Juluru, Bhasker [1 ]
机构：
[1] Chaitanya Deemed Be Univ, Dept Chem, Hanamkonda 506001, Telangana, India
[2] Jazan Univ, Dept Chem, Jazan, Saudi Arabia
[3] Telangana Univ, Organ Chem Dept, Nizamabad, Telangana, India
来源：
CHEMICAL DATA COLLECTIONS | 2023年 / 43卷
关键词：
Benoxaprofen; IMATINIB; Benzoxazole; Pyrimidine and anticancer activity; BIOLOGICAL EVALUATION; 1,3,4-OXADIAZOLE; BENZIMIDAZOLE;
D O I：
10.1016/j.cdc.2022.100971
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A unique library of amide functionality carrying bis-1,3,4-oxadiazole-oxazolo[4,5-b]pyridin-2-yl) derivatives (10a -j) with proven chemical structures has been synthesised. They were tested for preliminary anticancer properties against various human cancer cell lines such as human prostate cancer (PC3), human lung cancer (A549), human breast cancer (MCF-7) and human colon cancer (Colo -205) using the MTT assay and chemotherapeutic agents such as etoposide as the reference drug. When compared to etoposide, all drugs shown greater efficacy against all cell lines.
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页数：7
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