Detection of Abdominal Lymph Node Metastasis from Pancreatic Neuroendocrine Tumor by Somatostatin Receptor Scintigraphy: Comparison with Somatostatin Receptor Type 2 Immunostaining

被引：0

作者：

Kitajima, Kazuhiro ^{[1
]}

Shiomi, Hideyuki ^{[2
]}

Kihara, Takako ^{[3
]}

Hirono, Seiko ^{[4
]}

Nakano, Ryota ^{[2
]}

Okamoto, Tomohiro ^{[4
]}

Yagi, Chisako ^{[5
]}

Eda, Hirotsugu ^{[6
]}

Matsuda, Kosuke ^{[1
]}

Hatano, Michiko ^{[1
]}

Yoshida, Makoto ^{[3
]}

Kono, Hiroshi ^{[3
]}

Hirota, Seiichi ^{[3
]}

Minami, Tetsuya ^{[7
]}

Yamakado, Koichiro ^{[1
]}

机构：

[1] Hyogo Med Univ, Dept Radiol, Nishinomiya, Hyogo, Japan

[2] Hyogo Med Univ, Div Gastroenterol & Hepatobiliary Pancreatol, Dept Internal Med, Nishinomiya, Hyogo, Japan

[3] Hyogo Med Univ, Dept Surg Pathol, Nishinomiya, Hyogo, Japan

[4] Hyogo Med Univ, Dept Hepatobiliary Pancreat Surg, Nishinomiya, Hyogo, Japan

[5] Hyogo Med Univ, Dept Diabet Endocrinol & Clin Immunol, Nishinomiya, Hyogo, Japan

[6] Hyogo Med Univ, Div Gastroenterol & Hepatol, Dept Internal Med, Nishinomiya, Hyogo, Japan

[7] Kanazawa Med Univ, Dept Radiol, Uchinada, Ishikawa, Japan

来源：

CASE REPORTS IN ONCOLOGY | 2023年 / 16卷 / 01期

关键词：

Neuroendocrine neoplasm; Lymph node metastasis; Somatostatin receptor scintigraphy; Fluorodeoxyglucose positron emission tomography; ENDOCRINE TUMORS;

D O I：

10.1159/000531572

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a 58-year-old male with a histopathologically proven grade 2 (G2) pancreatic neuroendocrine neoplasm and multiple abdominal node metastases by use of a laparoscopic pancreatic body and tail resection procedure, plus abdominal lymph node dissection. A primary pancreatic tail neuroendocrine tumor sized 20 x 25 mm was detected by contrast-enhanced computed tomography, somatostatin receptor scintigraphy (SRS), and fluorodeoxyglucose positron emission tomography (FDG-PET) examinations and pathologically diagnosed as a pancreatic neuroendocrine tumor (PNET, G2) based on positive immunostaining for somatostatin receptor (SSTR) type 2. Of three metastatic histopathological lymph nodes, two measured 18 x 21 and 10 x 12 mm, respectively, with whole strong SSTR immunostaining showing moderate uptake in SRS findings, whereas the other node, sized 8 x 10 mm, had strong SSTR immunostaining only in a small 6 x 6-mm-sized portion and showed no uptake in SRS findings, likely because of the limited spatial resolution of scintigraphy. On the other hand, only the largest node (18 x 21 mm) was visualized by FDG-PET. SRS may be useful for metastatic lymph node diagnosis based on SSTR immunostaining, though a disadvantage is the spatial resolution limitation.

引用

页码：543 / 549

页数：7

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