The paradoxical role of transforming growth factor-β in controlling oral squamous cell carcinoma development

被引：0
作者：
Peng, Ruiting [1 ]
Huang, Yun [1 ]
Huang, Ping [1 ]
Liu, Linyi [2 ]
Cheng, Lei [3 ,4 ,5 ,6 ]
Peng, Xian [3 ,4 ,5 ]
机构：
[1] Gen Hosp Western Theater Command PLA, Dept Stomatol, Chengdu, Peoples R China
[2] Maine Hlth Inst Res, Scarborough, ME USA
[3] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China
[4] Sichuan Univ, West China Hosp Stomatol, Natl Ctr Stomatol, Chengdu 610041, Peoples R China
[5] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China
[6] Sichuan Univ, West China Hosp Stomatol, Dept Operat Dent & Endodont, Chengdu, Peoples R China
来源：
CANCER BIOMARKERS | 2024年 / 40卷 / 3-4期
关键词：
TGF-beta; OSCC; signal transduction; cell proliferation; cell apoptosis; cell migration; cell invasion; EMT; CANCER-ASSOCIATED FIBROBLASTS; IL-2; PRODUCTION; C-MYC; TGF-BETA-1; PROLIFERATION; METASTASIS; MODULATION; SENESCENCE; EXPRESSION; INDUCTION;
D O I：
10.3233/CBM-230354
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Transforming growth factor-/3 (TGF-/3) is a multifunctional cytokine that plays a vital role in regulating cell growth, differentiation and survival in various tissues. It participates in a variety of cellular processes, including cell apoptosis, cell migration and evasion, and plays a paradoxical role in tumor genesis and development. In the early stage of tumor, TGF-/3 inhibits the occurrence of tumor by inhibiting cell proliferation and regulating cell apoptosis. In the advanced stage of tumor, TGF-/3 promotes tumor development and affects prognosis by promoting cell survival and proliferation, cell migration and invasion, participates in immune escape, etc. In this article, we will review the paradoxical role of TGF-/3 on the occurrence and development of oral squamous cell carcinoma.
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收藏
页码：241 / 250
页数：10
相关论文
共 81 条
[1]   Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma [J].
Abd El-Aziz, Yomna S. ;
Leck, Lionel Y. W. ;
Jansson, Patric J. ;
Sahni, Sumit .
CANCERS, 2021, 13 (24)
[2]   TGF-β receptors: In and beyond TGF-β signaling [J].
Ark, Alexandra Vander ;
Cao, Jingchen ;
Li, Xiaohong .
CELLULAR SIGNALLING, 2018, 52 :112-120
[3]   TGF- β1-mediated Apoptosis Associated With SMAD-dependent Mitochondrial Bcl-2 Expression [J].
Bakhshayesh, Masoomeh ;
Zaker, Farhad ;
Hashemi, Mehrdad ;
Katebi, Majid ;
Solaimani, Mansooreh .
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2012, 12 (02) :138-143
[4]   Transforming Growth Factor-β Signaling in Immunity and Cancer [J].
Batlle, Eduard ;
Massague, Joan .
IMMUNITY, 2019, 50 (04) :924-940
[5]   p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest [J].
Braun, Christian J. ;
Zhang, Xin ;
Savelyeva, Irina ;
Wolff, Sonja ;
Moll, Ute M. ;
Schepeler, Troels ;
Orntoft, Torben F. ;
Andersen, Claus L. ;
Dobbelstein, Matthias .
CANCER RESEARCH, 2008, 68 (24) :10094-10104
[6]  
Bu JQ, 2017, EUR REV MED PHARMACO, V21, P2137
[7]   E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression [J].
Chen, CR ;
Kang, YB ;
Siegel, PM ;
Massagué, J .
CELL, 2002, 110 (01) :19-32
[8]   Cancer-associated fibroblasts regulate keratinocyte cell-cell adhesion via TGF-β-dependent pathways in genotype-specific oral cancer [J].
Cirillo, N. ;
Hassona, Y. ;
Celentano, A. ;
Lim, K. P. ;
Manchella, S. ;
Parkinson, E. K. ;
Prime, S. S. .
CARCINOGENESIS, 2017, 38 (01) :76-85
[9]   TGF-β and VEGF cooperatively control the immunotolerant tumor environment and the efficacy of cancer immunotherapies [J].
Courau, Tristan ;
Nehar-Belaid, Djamel ;
Florez, Laura ;
Levacher, Beatrice ;
Vazquez, Thomas ;
Brimaud, Faustine ;
Bellier, Bertrand ;
Klatzmann, David .
JCI INSIGHT, 2016, 1 (09)
[10]   TGF-β in T Cell Biology: Implications for Cancer Immunotherapy [J].
Dahmani, Amina ;
Delisle, Jean-Sebastien .
CANCERS, 2018, 10 (06)
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