Circulating microaggregates as biomarkers for the Post-COVID syndrome

被引：0

作者：

Hermann, M. ^{[1
]}

Lisch, C. ^{[2
]}

Gerth, R. ^{[3
]}

Wick, G. ^{[4
]}

Fries, D. ^{[4
]}

Wick, N. ^{[3
]}

机构：

[1] Med Univ Innsbruck, Dept Anesthesia & Intens Care, Innsbruck, Austria

[2] Sanat Hochrum, Rum, Austria

[3] Specialized Labs Wick, Speckbacherstr 23, A-6020 Innsbruck, Austria

[4] Innsbruck Med Univ, Div Pathophysiol, Bioctr, Innsbruck, Austria

来源：

IDCASES | 2024年 / 36卷

关键词：

Post-CoVID; Coagulation; Chronic fatigue;

D O I：

10.1016/j.idcr.2024.e02000

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

CoVID-19 can develop into Post-COVID syndrome of potentially high morbidity, with procoagulation and reactivation of dormant viral infections being hypothesized pathophysiological mechanisms. We report on a patient suffering from fatigue, post exertional malaise, pain and neurological symptoms as a consequence of the second CoVID infection. Using live confocal microscopy on native whole blood samples we detected microaggregates of thrombocytes, leukocytes and plasma proteins in peripheral blood. In addition, there was specific cellular immunological reactivity to EBV. Upon anticoagulatory and virustatic pharmacological therapy we observed dissolution of microaggregates and significant stable clinical remission. We suggest to consider circulating microaggregates as a morphological indicator of chronic post-COVID syndrome.

引用

页数：2