Ring-Closing Metathesis as Methodology for the Synthesis of 2-and 3-Arylbenzo[b]furans

被引：0

作者：

Visser, Melanie ^{[1
]}

Twigge, Linette ^{[1
]}

Marais, Charlene ^{[1
]}

Bezuidenhoudt, Barend C. B. ^{[1
]}

机构：

[1] Univ Free State, Dept Chem, POB 339, ZA-9300 Bloemfontein, South Africa

来源：

SYNTHESIS-STUTTGART | 2024年 / 56卷 / 22期

基金：

新加坡国家研究基金会;

关键词：

arylbenzofurans; metathesis; Grubbs catalyst; allylation; Tebbe methylenation; Grignard reagent; Al(OTf)(3); BIOACTIVE BENZOFURAN DERIVATIVES; CYCLIC ENOL ETHERS; CLAISEN REARRANGEMENT; CONVENIENT SYNTHESIS; EFFICIENT SYNTHESIS; CARBONYL-COMPOUNDS; PHENOLS; LITHIATION; REAGENT; ACID;

D O I：

10.1055/a-2367-2151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Olefin metathesis, which is well established in the petrochemical industry, is also emerging as a green technology in the manufacture of pharmaceutical and specialty chemicals. Arylbenzofurans are of interest for potential medicinal applications. In this paper we report on the synthesis of various 2-aryl- and 3-arylbenzo[ b ]furans with natural substitution patterns from readily available starting materials in a strategy that applies ring-closing metathesis with the Grubbs second generation catalyst as key step.

引用

页码：3488 / 3502

页数：15

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