Metabolic adaptations in prostate cancer

被引：8
作者：
Pujana-Vaquerizo, Mikel [1 ,2 ]
Bozal-Basterra, Laura [1 ]
Carracedo, Arkaitz [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC bioGUNE, Bizkaia Technol Pk,Bldg 800, Derio 48160, Spain
[2] Ctr Invest Biomed Red Canc CIBERONC, Madrid 28029, Spain
[3] Biobizkaia Hlth Res Inst, CIC BioGUNE Basurto, Traslat Prostate Canc Res Lab, Bilbao, Spain
[4] Ikerbasque, Basque Fdn Sci, Bilbao, Spain
[5] Univ Basque Country UPV EHU, Biochem & Mol Biol Dept, Leioa, Spain
来源：
BRITISH JOURNAL OF CANCER | 2024年 / 131卷 / 08期
基金：
欧盟地平线“2020”; 欧洲研究理事会;
关键词：
GLYCINE-N-METHYLTRANSFERASE; ONE-CARBON METABOLISM; FATTY-ACID SYNTHASE; T-CELL METABOLISM; BODY-MASS INDEX; ANDROGEN RECEPTOR; CASTRATION-RESISTANT; ORNITHINE-DECARBOXYLASE; TUMOR MICROENVIRONMENT; LIPID-METABOLISM;
D O I：
10.1038/s41416-024-02762-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer is one of the most commonly diagnosed cancers in men and is a major cause of cancer-related deaths worldwide. Among the molecular processes that contribute to this disease, the weight of metabolism has been placed under the limelight in recent years. Tumours exhibit metabolic adaptations to comply with their biosynthetic needs. However, metabolites also play an important role in supporting cell survival in challenging environments or remodelling the tumour microenvironment, thus being recognized as a hallmark in cancer. Prostate cancer is uniquely driven by androgen receptor signalling, and this knowledge has also influenced the paths of cancer metabolism research. This review provides a comprehensive perspective on the metabolic adaptations that support prostate cancer progression beyond androgen signalling, with a particular focus on tumour cell intrinsic and extrinsic pathways.
引用
收藏
页码：1250 / 1262
页数：13
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