Advances of Oxidative Stress Impact in Periodontitis: Biomarkers and Effective Targeting Options

被引:3
作者
Pouliou, Chrysi [1 ]
Piperi, Christina [1 ,2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Dent Sch, 2 Thivon Str, Athens 11527, Greece
[2] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, 75 M Asias St, Athens 11527, Greece
关键词
Oxidative stress; periodontitis; reactive oxygen species; antioxidants; carotenoids; curcumin; resveratrol; CHEMICALLY-MODIFIED CURCUMIN; GINGIVAL CREVICULAR FLUID; NF-KAPPA-B; REACTIVE OXYGEN; IN-VITRO; CYTOKINE PRODUCTION; LIPID-PEROXIDATION; BONE-RESORPTION; FREE-RADICALS; PERIPHERAL NEUTROPHILS;
D O I
10.2174/0109298673297545240507091410
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Periodontitis is the most common inflammatory oral disease that affects around 15% of adults and contributes to severe periodontal tissue destruction with subsequent tooth loosening and loss. Among the main pathogenic mechanisms underlying periodontitis, excessive reactive oxygen species production and oxidative stress play a predominant role in inducing both local and systemic damage. Current therapeutic approaches have expanded the conventional methods combined with herbal antioxidant compounds to free radical-scavenging nanomaterials and infrared laser therapy, offering promising pre-clinical evidence in periodontitis management. Herein, we review the pathogenic mechanisms of reactive oxygen species tissue damage, along with recent advances in oxidative stress biomarkers and novel targeting options.
引用
收藏
页码:6187 / 6203
页数:17
相关论文
共 165 条
[1]   Evaluation of Salivary and Serum Antioxidant and Oxidative Stress Statuses in Patients with Chronic Periodontitis: A Case-Control Study [J].
Ahmadi-Motamayel, Fatemeh ;
Goodarzi, Mohammad T. ;
Jamshidi, Zohreh ;
Kebriaei, Reza .
FRONTIERS IN PHYSIOLOGY, 2017, 8
[2]   Salivary and serum oxidative stress biomarkers and advanced glycation end products in periodontitis patients with or without diabetes: A cross-sectional study [J].
Altingoz, Sema Merve ;
Kurgan, Sivge ;
Onder, Canan ;
Serdar, Muhittin A. ;
Unluturk, Ugur ;
Uyanik, Metin ;
Baskal, Nilgun ;
Tatakis, Dimitris N. ;
Gunhan, Meral .
JOURNAL OF PERIODONTOLOGY, 2021, 92 (09) :1274-1285
[3]   Development of pH-responsive biopolymer-silica composites loaded with Larrea divaricata Cav. extract with antioxidant activity [J].
Alvarez Echazu, Maria Ines ;
Ezequiel Olivetti, Christian ;
Peralta, Ignacio ;
Rosario Alonso, Maria ;
Anesini, Claudia ;
Javier Perez, Claudio ;
Solange Alvarez, Gisela ;
Federico Desimone, Martin .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 169 :82-91
[4]   Effect of resveratrol and modulation of cytokine production on human periodontal ligament cells [J].
Antonietta, Rizzo ;
Nazario, Bevilacqua ;
Luigi, Guida ;
Marco, Annunziata ;
Caterina, Romano Carratelli ;
Rossella, Paolillo .
CYTOKINE, 2012, 60 (01) :197-204
[5]   Polydopamine Nanoparticles as Efficient Scavengers for Reactive Oxygen Species in Periodontal Disease [J].
Bao, Xingfu ;
Zhao, Jiahui ;
Sun, Jian ;
Hu, Min ;
Yang, Xiurong .
ACS NANO, 2018, 12 (09) :8882-8892
[6]  
Batchu SN, 2013, BIOACT FOOD CHRON, P431, DOI 10.1016/B978-0-12-396485-4.00026-8
[7]   Oxidative injury and inflammatory periodontal diseases: The challenge of antioxidants to free radicals and reactive oxygen species [J].
Battino, M ;
Bullon, P ;
Wilson, M ;
Newman, H .
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1999, 10 (04) :458-476
[8]   Tea polyphenols inhibit the growth and virulence properties of Fusobacterium nucleatum [J].
Ben Lagha, Amel ;
Haas, Bruno ;
Grenier, Daniel .
SCIENTIFIC REPORTS, 2017, 7
[9]   Wild Blueberry (Vaccinium angustifolium Ait.) Polyphenols Target Fusobacterium nucleatum and the Host Inflammatory Response: Potential Innovative Molecules for Treating Periodontal Diseases [J].
Ben Lagha, Amel ;
Dudonne, Stephanie ;
Desjardins, Yves ;
Grenier, Daniel .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, 63 (31) :6999-7008
[10]   ORAL HEALTH: THE SILENT EPIDEMIC [J].
Benjamin, Regina M. .
PUBLIC HEALTH REPORTS, 2010, 125 (02) :158-159