Recent Advances in IRAK1: Pharmacological and Therapeutic Aspects

被引：10

作者：

Kim, Kyeong Min ^{[1
]}

Hwang, Na-Hee ^{[1
]}

Hyun, Ja-Shil ^{[1
]}

Shin, Dongyun ^{[1
]}

机构：

[1] Gachon Univ, Coll Pharm, Hambakmoe Ro 191, Incheon 21935, South Korea

来源：

MOLECULES | 2024年 / 29卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

interleukin receptor-associated kinase (IRAK) proteins; inhibitor; degrader; immunity; SIGNALING MEDIATOR; KINASE IRAK; INNATE; ACTIVATION; INFLAMMATION; INHIBITORS; FAMILY; NEUROINFLAMMATION; IDENTIFICATION; MICRORNA-146A;

D O I：

10.3390/molecules29102226

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin receptor-associated kinase (IRAK) proteins are pivotal in interleukin-1 and Toll-like receptor-mediated signaling pathways. They play essential roles in innate immunity and inflammation. This review analyzes and discusses the physiological functions of IRAK1 and its associated diseases. IRAK1 is involved in a wide range of diseases such as dry eye, which highlights its potential as a therapeutic target under various conditions. Various IRAK1 inhibitors, including Pacritinib and Rosoxacin, show therapeutic potential against malignancies and inflammatory diseases. The covalent IRAK1 inhibitor JH-X-119-01 shows promise in B-cell lymphomas, emphasizing the significance of covalent bonds in its activity. Additionally, the emergence of selective IRAK1 degraders, such as JNJ-101, provides a novel strategy by targeting the scaffolding function of IRAK1. Thus, the evolving landscape of IRAK1-targeted approaches provides promising avenues for increasingly safe and effective therapeutic interventions for various diseases.

引用

页数：17

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