The roles of long non-coding RNAs in Alzheimer's disease diagnosis, treatment, and their involvement in Alzheimer's disease immune responses

被引：7
作者：
Wu, Xiaoben [1 ]
Xia, Pengcheng [1 ]
Yang, Lei [2 ]
Lu, Chao [1 ]
Lu, Zhiming [1 ]
机构：
[1] Shandong First Med Univ, Shandong Prov Hosp, Dept Clin Lab, Jinan, Peoples R China
[2] Shandong First Med Univ, Shandong Prov Hosp, Dept Med Engn, Jinan, Peoples R China
来源：
NON-CODING RNA RESEARCH | 2024年 / 9卷 / 03期
关键词：
Alzheimer's disease; Long non -coding RNA; Diagnosis; Treatment; Progression; NEURODEGENERATIVE DISEASES; EPIGENETIC REGULATORS; INNATE IMMUNITY; NEAT1; TARGET; ACTIVATION; MECHANISMS; BIOMARKERS; BC200; MICE;
D O I：
10.1016/j.ncrna.2024.03.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is the most frequent type of dementia, presenting a substantial danger to the health and well-being of the aged population. It has arisen as a significant public health problem with considerable socioeconomic repercussions. Unfortunately, no effective treatments or diagnostic tools are available for Alzheimer's disease. Despite substantial studies on the pathophysiology of Alzheimer's, the molecular pathways underpinning its development remain poorly understood. Long non-coding RNAs (lncRNAs) vary in size from 200 nucleotides to over 100 kilobytes and have been found to play critical roles in various vital biological processes that play critical in developing Alzheimer's disease. This review intends to examine the functions of long non-coding RNAs in diagnosing and treating Alzheimer's disease and their participation in immunological responses associated with AD.
引用
收藏
页码：659 / 666
页数：8
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