Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment

被引:1
作者
Jung, Na-Yeon [1 ]
Je, Yuri [2 ,3 ]
Ham, Hong-Gi [4 ]
Park, Yu Hyun [4 ]
Kim, Tae-Yun [2 ,3 ]
Go, Min-su [2 ,3 ]
Lee, Hye-In [2 ,3 ]
Kim, Da Eun [2 ,3 ]
Lee, Myung Jun [2 ,3 ]
Seo, Sang Won [4 ]
Kim, Eun-Joo [2 ,3 ,5 ]
机构
[1] Pusan Natl Univ, Yangsan Hosp, Dept Neurol, Sch Med, Yangsan, South Korea
[2] Pusan Natl Univ, Sch Med, Pusan Natl Univ Hosp, Dept Neurol, 179 Gudeok Ro, Busan 49241, South Korea
[3] Biomed Res Inst, Busan 49241, South Korea
[4] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Neurol, Seoul, South Korea
[5] Med Res Inst, 179 Gudeok Ro, Busan 49241, South Korea
关键词
enlarged perivascular spaces; cerebral amyloid angiopathy; cerebral small vessel disease; centrum semiovale; Alzheimer disease; MRI;
D O I
10.1097/WAD.0000000000000614
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We examined whether there were differences in the presence of centrum semiovale-enlarged perivascular spaces (CSO-ePVS) and basal ganglia-ePVS (BG-ePVS) among patients with Alzheimer disease-related cognitive impairment (ADCI) based on their age of onset. Out of a total of 239 patients with cognitive impairment, 155 with positive amyloid-PET results were included. Among these, 43 had early-onset ADCI (EOADCI) and 112 had late-onset ADCI (LOADCI). Patients with LOADCI exhibited a higher prevalence of hypertension, lacunes, white matter hyperintensities, and BG-ePVS than those with EOADCI. BG-ePVS showed a significant correlation with age at the onset and the number of lacunes, whereas CSO-ePVS did not exhibit any association. The higher prevalence of BG-ePVS in patients with LOADCI might be attributable to vascular risk factors (hypertension) and cerebral small vessel disease (CSVD). These findings support the hypothesis that BG-ePVS is associated with CSVD and vascular risk factors, whereas CSO-ePVS is associated with cerebral amyloid angiopathy.
引用
收藏
页码:201 / 204
页数:4
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